DDX11

Name	DEAD/H-box helicase 11
Structure	No pdb structure
Novel Interactors	1 novel interactors: PKP2
Interactors	4 interactors: EIF4ENIF1 KAT7 PFN2 PRRC2B
GO Annotations	Cellular Component	Chromatin Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytoskeleton Midbody Mitotic Cohesin Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent Activity, Acting On RNA Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding G-quadruplex DNA Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Replication Fork Processing Negative Regulation Of Protein Binding Establishment Of Sister Chromatid Cohesion Positive Regulation Of Chromatin Binding Positive Regulation Of Sister Chromatid Cohesion Cellular Response To Hydroxyurea Cellular Response To Cisplatin Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Bleomycin Nucleolar Chromatin Organization Positive Regulation Of Double-strand Break Repair
Pathways	XBP1(S) activates chaperone genes
Diseases	Warsaw breakage syndrome
GWAS	No GWAS studies recorded
Entrez ID	1663
HPRD ID	03095
Ensembl ID	ENSG00000013573
Uniprot IDs	Q2NKM7 Q96FC9
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Maintenance Of Protein Localization At Cell Tip Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Histone H3-K14 Acetyltransferase Complex Response To Dithiothreitol Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Maintenance Of Animal Organ Identity Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Alpha-catenin Binding Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Intermediate Filament Bundle Assembly Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Desmosome Assembly Internal Protein Amino Acid Acetylation Response To Anisomycin Internal Peptidyl-lysine Acetylation DNA Replication-dependent Chromatin Disassembly Response To Hydroxyurea Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Response To Sorbitol Histone H3 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Response To Actinomycin D Positive Regulation Of Hematopoietic Stem Cell Proliferation Histone H4 Acetyltransferase Activity Nuclear Export Signal Receptor Activity Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Peptidyl-lysine Acetylation Negative Regulation Of Epithelial Cell Migration Regulation Of Actin Filament-based Process Desmosome Organization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding P-body Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Hematopoietic Stem Cell Proliferation Natural Killer Cell Differentiation Modification Of Postsynaptic Structure