DDX11 and EIF4ENIF1

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		DDX11	EIF4ENIF1
Name		DEAD/H-box helicase 11	eukaryotic translation initiation factor 4E nuclear import factor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytoskeleton Midbody Mitotic Cohesin Complex Extracellular Exosome	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent Activity, Acting On RNA Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding G-quadruplex DNA Binding Catalytic Activity, Acting On A Nucleic Acid	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Replication Fork Processing Negative Regulation Of Protein Binding Establishment Of Sister Chromatid Cohesion Positive Regulation Of Chromatin Binding Positive Regulation Of Sister Chromatid Cohesion Cellular Response To Hydroxyurea Cellular Response To Cisplatin Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Bleomycin Nucleolar Chromatin Organization Positive Regulation Of Double-strand Break Repair	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Pathways		XBP1(S) activates chaperone genes	None
Diseases		Warsaw breakage syndrome	None
GWAS		No GWAS studies recorded	Age-related hearing impairment ( 24939585 ) Fish- and plant-related diet ( 32066663 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 )
Interacting Genes		4 interacting genes: EIF4ENIF1 KAT7 PFN2 PRRC2B	92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6
Entrez ID		1663	56478
HPRD ID		03095	10456
Ensembl ID		ENSG00000013573	ENSG00000184708
Uniprot IDs		Q2NKM7 Q96FC9	Q9NRA8
PDB IDs		Not available	5ANR 6F9W 6X2R
GO Terms Enriched among Interactors		Maintenance Of Protein Localization At Cell Tip Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Histone H3-K14 Acetyltransferase Complex Response To Dithiothreitol Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Maintenance Of Animal Organ Identity Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Alpha-catenin Binding Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Intermediate Filament Bundle Assembly Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Desmosome Assembly Internal Protein Amino Acid Acetylation Response To Anisomycin Internal Peptidyl-lysine Acetylation DNA Replication-dependent Chromatin Disassembly Response To Hydroxyurea Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Response To Sorbitol Histone H3 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Response To Actinomycin D Positive Regulation Of Hematopoietic Stem Cell Proliferation Histone H4 Acetyltransferase Activity Nuclear Export Signal Receptor Activity Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Peptidyl-lysine Acetylation Negative Regulation Of Epithelial Cell Migration Regulation Of Actin Filament-based Process Desmosome Organization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding P-body Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Hematopoietic Stem Cell Proliferation Natural Killer Cell Differentiation Modification Of Postsynaptic Structure	RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity