CXCL12 and XCL1

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CXCL12	XCL1
Description		C-X-C motif chemokine ligand 12	X-C motif chemokine ligand 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding
	Biological Process	Response To Hypoxia Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Intracellular Calcium Ion Homeostasis Chemotaxis Defense Response Immune Response Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Axon Guidance Blood Circulation Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Response To Mechanical Stimulus Response To Virus T Cell Chemotaxis Telencephalon Cell Migration Positive Regulation Of Cell Migration Animal Organ Regeneration Killing Of Cells Of Another Organism Positive Regulation Of Dopamine Secretion Integrin Activation Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway CXCL12-activated CXCR4 Signaling Pathway Response To Peptide Hormone Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Chemotaxis Induction Of Positive Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Vasculature Development Response To Ultrasound Cellular Response To Chemokine Positive Regulation Of T Cell Migration Negative Regulation Of Dendritic Cell Apoptotic Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Nuclear signaling by ERBB4 Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Estrogen-dependent gene expression	Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs		CTCE-0214 Tinzaparin
Diseases
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Blood protein levels ( 30072576) Body mass index ( 25760438) Coronary artery disease ( 32469254 24262325 26708285 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449 21378990) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Myeloid white cell count ( 27863252) Myocardial infarction ( 26343387 33532862) Myocardial infarction (early onset) ( 19198609) Neutrophil count ( 27863252 32888494) QT interval (ambient particulate matter interaction) ( 28749367) Red blood cell count ( 32888494) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Schizophrenia ( 23212062) Smoking initiation (ever regular vs never regular) ( 31089300) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483) Psoriasis ( 34927100)
Interacting Genes		30 interacting genes: CCL11 CCL13 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CD4 CTSG CXCL10 CXCL11 CXCL14 CXCL17 CXCL2 CXCL6 CXCL9 CXCR4 DAZAP2 DPP4 ELANE FBXO7 FN1 MMP2 PF4 PF4V1 PPBP VCAN XCL1 XCL2	19 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 KRTAP10-3 PF4 PF4V1 VCAN XCR1
Entrez ID		6387	6375
HPRD ID		02904	02595
Ensembl ID		ENSG00000107562	ENSG00000143184
Uniprot IDs		P48061	P47992
PDB IDs		1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2N55 2NWG 2SDF 3GV3 3HP3 4LMQ 4UAI 6SHR 7SK3 7SK4 7SK5 7SK6 7SK7 7SK8 8K3Z 8U4O	1J8I 1J9O 2HDM 2JP1 2N54 2NYZ 9AST
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Leukocyte Chemotaxis Leukocyte Migration Cell Migration Humoral Immune Response Cytokine Activity Myeloid Leukocyte Migration Cell Motility Killing Of Cells Of Another Organism Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Cell Killing Chemokine-mediated Signaling Pathway Defense Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Extracellular Space Response To Other Organism Immune Response Response To External Biotic Stimulus Mononuclear Cell Migration Extracellular Region Cytokine-mediated Signaling Pathway CXCR Chemokine Receptor Binding CCR Chemokine Receptor Binding Response To Stress Regulation Of Locomotion Neutrophil Chemotaxis Regulation Of Cell Migration Neutrophil Migration Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Binding Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway CXCR3 Chemokine Receptor Binding Response To Molecule Of Bacterial Origin Signal Transduction Cellular Response To Lipid	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine Activity Antimicrobial Humoral Response Chemotaxis Locomotion Leukocyte Chemotaxis Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Migration Granulocyte Migration Cell Motility Killing Of Cells Of Another Organism Extracellular Space Cell Killing Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism CXCR Chemokine Receptor Binding Immune System Process Defense Response Extracellular Region Response To Other Organism Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration CCR Chemokine Receptor Binding Response To External Biotic Stimulus CXCR3 Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemokine Receptor Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell-cell Signaling Signaling Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Cell Communication
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