CXCL12 and ELANE

Number of citations of the paper that reports this interaction (PubMedID 12068293)
0

Data Source:
HPRD (in vitro)

		CXCL12	ELANE
Description		C-X-C motif chemokine ligand 12	elastase, neutrophil expressed
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding
	Biological Process	Response To Hypoxia Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Intracellular Calcium Ion Homeostasis Chemotaxis Defense Response Immune Response Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Axon Guidance Blood Circulation Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Response To Mechanical Stimulus Response To Virus T Cell Chemotaxis Telencephalon Cell Migration Positive Regulation Of Cell Migration Animal Organ Regeneration Killing Of Cells Of Another Organism Positive Regulation Of Dopamine Secretion Integrin Activation Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway CXCL12-activated CXCR4 Signaling Pathway Response To Peptide Hormone Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Chemotaxis Induction Of Positive Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Vasculature Development Response To Ultrasound Cellular Response To Chemokine Positive Regulation Of T Cell Migration Negative Regulation Of Dendritic Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Nuclear signaling by ERBB4 Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Estrogen-dependent gene expression	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes
Drugs		CTCE-0214 Tinzaparin	Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Blood protein levels ( 30072576) Body mass index ( 25760438) Coronary artery disease ( 32469254 24262325 26708285 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449 21378990) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Myeloid white cell count ( 27863252) Myocardial infarction ( 26343387 33532862) Myocardial infarction (early onset) ( 19198609) Neutrophil count ( 27863252 32888494) QT interval (ambient particulate matter interaction) ( 28749367) Red blood cell count ( 32888494) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Schizophrenia ( 23212062) Smoking initiation (ever regular vs never regular) ( 31089300) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	Blood protein levels ( 30072576)
Interacting Genes		30 interacting genes: CCL11 CCL13 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CD4 CTSG CXCL10 CXCL11 CXCL14 CXCL17 CXCL2 CXCL6 CXCL9 CXCR4 DAZAP2 DPP4 ELANE FBXO7 FN1 MMP2 PF4 PF4V1 PPBP VCAN XCL1 XCL2	31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		6387	1991
HPRD ID		02904	00554
Ensembl ID		ENSG00000107562	ENSG00000197561
Uniprot IDs		P48061	P08246
PDB IDs		1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2N55 2NWG 2SDF 3GV3 3HP3 4LMQ 4UAI 6SHR 7SK3 7SK4 7SK5 7SK6 7SK7 7SK8 8K3Z 8U4O	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Leukocyte Chemotaxis Leukocyte Migration Cell Migration Humoral Immune Response Cytokine Activity Myeloid Leukocyte Migration Cell Motility Killing Of Cells Of Another Organism Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Cell Killing Chemokine-mediated Signaling Pathway Defense Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Extracellular Space Response To Other Organism Immune Response Response To External Biotic Stimulus Mononuclear Cell Migration Extracellular Region Cytokine-mediated Signaling Pathway CXCR Chemokine Receptor Binding CCR Chemokine Receptor Binding Response To Stress Regulation Of Locomotion Neutrophil Chemotaxis Regulation Of Cell Migration Neutrophil Migration Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Binding Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway CXCR3 Chemokine Receptor Binding Response To Molecule Of Bacterial Origin Signal Transduction Cellular Response To Lipid	Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process
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