VCAN and FBLN2

Number of citations: 0 (PubMedID 11038354)
Data Source: HPRD (in vitro)

		VCAN	FBLN2
Name		versican	fibulin 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Cell Projection Lysosomal Lumen Synapse Perineuronal Net	Extracellular Region Extracellular Matrix Extracellular Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Protein Tyrosine Phosphatase Activator Activity Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Cell Adhesion Central Nervous System Development Cell Recognition Glial Cell Migration System Development	Positive Regulation Of Cell-substrate Adhesion
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Hyaluronic acid	None
Diseases		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)	None
GWAS		Appendicular lean mass ( 33097823 28724990 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Carotid intima media thickness (mean) ( 31801372 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical volume ( 32963231 ) Diisocyanate-induced asthma ( 25918132 ) Gastroesophageal reflux disease ( 31527586 ) HDL cholesterol levels ( 32203549 ) Joint mobility (Beighton score) ( 27182965 ) Laryngeal squamous cell carcinoma ( 25194280 ) Lean body mass ( 28724990 ) Major depressive disorder ( 20516156 ) Optic disc size ( 31809533 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32203549 ) Vertical cup-disc ratio ( 28073927 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) White matter hyperintensity volume ( 29752348 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter integrity (fractional anisotropy) ( 29752348 32358547 ) White matter integrity (mean diffusivity) ( 29752348 32358547 )	Appendicular lean mass ( 33097823 ) Bipolar disorder with mood-incongruent psychosis ( 23092984 ) Body mass index ( 26426971 ) Hip circumference adjusted for BMI ( 34021172 ) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097 )
Novel Interactors		None recorded	1 novel interactors: MRPS25
Interacting Genes		24 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A PTPRF RAB19 SELL SELP SELPLG TNR XCL1	32 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL8A1 ELN ERCC6 FBN1 FBXW5 FN1 HOXA1 HSD3B7 HSPG2 ITGB3 JOSD1 LAMA1 LAMA5 LAMC2 LCE3D NID1 NUFIP2 OTX1 PRELP VCAN ZNF408 ZNF414
Entrez ID		1462	2199
HPRD ID		00340	00630
Ensembl ID		ENSG00000038427	ENSG00000163520
Uniprot IDs		P13611 Q59FG9 Q86W61	P98095 Q86V58
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Leukocyte Migration Chemokine Activity Cell Migration Cell Motility Positive Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of T Cell Migration Regulation Of Lymphocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Regulation Of Leukocyte Migration Regulation Of T Cell Migration Antimicrobial Humoral Response Positive Regulation Of Mononuclear Cell Migration Cell Adhesion Leukocyte Cell-cell Adhesion Mononuclear Cell Migration Inflammatory Response Extracellular Space Regulation Of Cell Migration Killing Of Cells Of Another Organism Cell Chemotaxis Cytokine Activity Regulation Of Cell Motility Granulocyte Chemotaxis Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Locomotion Regulation Of Mononuclear Cell Migration Heparin Binding Granulocyte Migration Humoral Immune Response Extracellular Region Leukocyte Tethering Or Rolling Cell Killing Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Adhesion CCR Chemokine Receptor Binding Chemotaxis Myeloid Leukocyte Migration Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Locomotion Chemokine Receptor Binding Regulation Of Leukocyte Cell-cell Adhesion Response To Cytokine Response To Peptide	Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Region Collagen-activated Signaling Pathway Cell Adhesion Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Extracellular Structure Organization Extracellular Matrix Organization Integrin Binding Lysosomal Lumen Perineuronal Net Glomerular Basement Membrane Development Skeletal System Development Golgi Lumen Angiogenesis System Development Hyaluronic Acid Binding Extracellular Matrix Binding Endodermal Cell Differentiation Retinal Blood Vessel Morphogenesis Extracellular Space Substrate Adhesion-dependent Cell Spreading Regulation Of Basement Membrane Organization Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Blood Coagulation, Fibrin Clot Formation Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Extracellular Matrix Constituent Conferring Elasticity Central Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin-like Growth Factor Stimulus Cell-substrate Adhesion Heparin Binding Branching Involved In Salivary Gland Morphogenesis Proteoglycan Binding Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Response To Activity Protein Activation Cascade Regulation Of Cell Adhesion Regulation Of Cell-substrate Adhesion Regulation Of Integrin-mediated Signaling Pathway