VCAN and ADAMTS1

Number of citations of the paper that reports this interaction (PMID 11278559)
77

Data Source:
HPRD (in vitro, in vivo)

		VCAN	ADAMTS1
Gene Name		versican	ADAM metallopeptidase with thrombospondin type 1 motif, 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Intracellular Membrane-bounded Organelle	Basement Membrane Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Carbohydrate Binding	Metalloendopeptidase Activity Heparin Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Carbohydrate Metabolic Process Cell Adhesion Multicellular Organismal Development Central Nervous System Development Heart Development Cell Recognition Glial Cell Migration Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Proliferation Heart Trabecula Formation
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS		Major depressive disorder ( 20516156)
Protein-Protein Interactions		24 interactors: ACAN ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 CXCR3 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A SELL SELP SELPLG TNR XCL1	5 interactors: A2M ACAN FURIN VCAN VEGFA
Entrez ID		1462	9510
HPRD ID		00340	05530
Ensembl ID		ENSG00000038427	ENSG00000154734
Uniprot IDs		P13611 Q59FG9 Q6MZK8 Q86W61	Q8NE26 Q9UHI8
PDB IDs			2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Cell Migration Cell Motility Regulation Of Leukocyte Migration Locomotion Positive Regulation Of Leukocyte Migration Cell Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Behavior Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Regulation Of Chemotaxis Regulation Of Cell Migration Inflammatory Response Regulation Of Cell Motility Immune System Process Regulation Of Behavior Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Chemokine-mediated Signaling Pathway Response To Other Organism Extracellular Matrix Organization Extracellular Structure Organization Response To Biotic Stimulus Regulation Of Immune System Process Cellular Extravasation Lymphocyte Migration Response To External Stimulus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Single Organismal Cell-cell Adhesion Response To Organic Substance Defense Response Positive Regulation Of Cell Adhesion Lymphocyte Chemotaxis T Cell Migration Cellular Response To Cytokine Stimulus	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Pathogenesis Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Platelet Degranulation Secretion By Cell Glycosaminoglycan Biosynthetic Process Secretion Proteoglycan Metabolic Process Positive Regulation Of Protein Kinase D Signaling Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Basophil Chemotaxis Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Nerve Growth Factor Production Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Vein Morphogenesis Primitive Erythrocyte Differentiation VEGF-activated Neuropilin Signaling Pathway Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Glycosaminoglycan Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Deacetylase Activity Platelet Activation Positive Regulation Of Lymphangiogenesis Cardiac Vascular Smooth Muscle Cell Development Nerve Growth Factor Processing Positive Regulation Of Mast Cell Chemotaxis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity
Tagcloud ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt	adjuvant antitumor cdna cultured doses exert facilitate fold foundation hypericin led mcf mcf7 metastasis mfc michigan ml mug prevent purpose real separately subjected suppressive transcribed viability xtt
Tagcloud (Difference) ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt	adjuvant antitumor cdna cultured doses exert facilitate fold hypericin led mcf mcf7 metastasis mfc michigan ml mug prevent purpose real separately subjected suppressive transcribed viability xtt
Tagcloud (Intersection) ?		foundation