VCAN and CCL20

Number of citations of the paper that reports this interaction (PMID 11083865)
32

Data Source:
HPRD (in vitro)

		VCAN	CCL20
Gene Name		versican	chemokine (C-C motif) ligand 20
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Carbohydrate Binding	Protein Binding Chemokine Activity
	Biological Process	Skeletal System Development Osteoblast Differentiation Carbohydrate Metabolic Process Cell Adhesion Multicellular Organismal Development Central Nervous System Development Heart Development Cell Recognition Glial Cell Migration Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Wound Healing Defense Response To Bacterium Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Chemotaxis Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of T Cell Migration
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Major depressive disorder ( 20516156)	Blood pressure ( 17903302) Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		24 interactors: ACAN ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 CXCR3 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A SELL SELP SELPLG TNR XCL1	3 interactors: CCR6 TGFB3 VCAN
Entrez ID		1462	6364
HPRD ID		00340	03571
Ensembl ID		ENSG00000038427	ENSG00000115009
Uniprot IDs		P13611 Q59FG9 Q6MZK8 Q86W61	P78556
PDB IDs			1M8A 2HCI 2JYO
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Cell Migration Cell Motility Regulation Of Leukocyte Migration Locomotion Positive Regulation Of Leukocyte Migration Cell Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Behavior Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Regulation Of Chemotaxis Regulation Of Cell Migration Inflammatory Response Regulation Of Cell Motility Immune System Process Regulation Of Behavior Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Chemokine-mediated Signaling Pathway Response To Other Organism Extracellular Matrix Organization Extracellular Structure Organization Response To Biotic Stimulus Regulation Of Immune System Process Cellular Extravasation Lymphocyte Migration Response To External Stimulus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Single Organismal Cell-cell Adhesion Response To Organic Substance Defense Response Positive Regulation Of Cell Adhesion Lymphocyte Chemotaxis T Cell Migration Cellular Response To Cytokine Stimulus	Detection Of Hypoxia Uterine Wall Breakdown Ossification Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Frontal Suture Morphogenesis Detection Of Oxygen Extracellular Matrix Organization Extracellular Structure Organization Embryonic Neurocranium Morphogenesis SMAD Protein Import Into Nucleus Dermatan Sulfate Biosynthetic Process Cranial Suture Morphogenesis Dermatan Sulfate Proteoglycan Biosynthetic Process Skeletal System Development Dermatan Sulfate Proteoglycan Metabolic Process Positive Regulation Of SMAD Protein Import Into Nucleus Dendritic Cell Chemotaxis Chondroitin Sulfate Catabolic Process Regulation Of SMAD Protein Import Into Nucleus Craniofacial Suture Morphogenesis Response To Laminar Fluid Shear Stress Chondroitin Sulfate Biosynthetic Process Dendritic Cell Migration Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Cell Motility Positive Regulation Of Filopodium Assembly Response To Fluid Shear Stress Face Morphogenesis Regulation Of Collagen Metabolic Process Positive Regulation Of Bone Mineralization Head Morphogenesis Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Regulation Of Filopodium Assembly Salivary Gland Development Negative Regulation Of DNA Replication Response To Progesterone Face Development Lung Alveolus Development Cellular Defense Response Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Proteoglycan Biosynthetic Process
Tagcloud ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Difference) ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Intersection) ?