CD244 and CD247

Number of citations of the paper that reports this interaction (PMID 16049493)
63

Data Source:
HPRD (in vitro)

		CD244	CD247
Gene Name		CD244 molecule, natural killer cell receptor 2B4	CD247 molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Receptor Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Signal Transduction Blood Coagulation Leukocyte Migration	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways		Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)	Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		5 interactors: ARHGEF7 CD247 CD48 LAT SH2D1B	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		51744	919
HPRD ID		16121	01729
Ensembl ID		ENSG00000122223	ENSG00000198821
Uniprot IDs		Q9BZW8	P20963
PDB IDs			1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Cell Adhesion Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Lamellipodium Morphogenesis Fc Receptor Signaling Pathway Regulation Of Lamellipodium Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of T Cell Activation Regulation Of Immune System Process Defense Response Positive Regulation Of Fibroblast Migration Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Lamellipodium Organization Leukocyte Activation Positive Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Mast Cell Degranulation Regulation Of Body Fluid Levels Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Wound Healing Mast Cell Mediated Immunity Small GTPase Mediated Signal Transduction Focal Adhesion Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Fibroblast Migration Lysosome Localization Mast Cell Activation Cell Activation Response To Wounding Leukocyte Degranulation Lamellipodium Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Assembly Lamellipodium Organization Negative Regulation Of ERBB Signaling Pathway	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		accounting acpa aetiology apca apparently character citrullinated contradictory ctla4 deiminase drb1 genetics heritability histocompatibility hla incompletely interpreted mhc originated padi4 peptidylarginine ptpn22 ra rheumatoid stat4 subsets synovium update vital	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		accounting acpa aetiology apca apparently character citrullinated contradictory ctla4 deiminase drb1 genetics heritability histocompatibility hla incompletely interpreted mhc originated padi4 peptidylarginine ptpn22 ra rheumatoid stat4 subsets synovium update vital	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?