IFNLR1 and IFNL1

Number of citations of the paper that reports this interaction (PMID 12469119)
211

Data Source:
HPRD (in vivo)

		IFNLR1	IFNL1
Gene Name		interferon, lambda receptor 1	interferon, lambda 1
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Interleukin-28 Receptor Complex	Extracellular Region Extracellular Space Interleukin-28 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding	Receptor Binding Cytokine Activity Interleukin-28 Receptor Binding
	Biological Process	Mucosal Immune Response Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Regulation Of Defense Response To Virus By Host Defense Response To Virus	Negative Regulation Of Type 2 Immune Response JAK-STAT Cascade Negative Regulation Of Cell Proliferation Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Memory T Cell Differentiation Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Immune Response Defense Response To Virus
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: IFNL1 IFNL2 LSM8	1 interactors: IFNLR1
Entrez ID		163702	282618
HPRD ID		09589	09588
Ensembl ID		ENSG00000185436	ENSG00000182393
Uniprot IDs		Q8IU57	Q8IU54
PDB IDs		3OG4 3OG6	3OG4 3OG6
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Negative Regulation Of Memory T Cell Differentiation Defense Response To Virus Response To Virus Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Immune Response Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Type 2 Immune Response Response To Other Organism Response To Biotic Stimulus Regulation Of Interleukin-5 Production Regulation Of Immune Response Mucosal Immune Response Positive Regulation Of Immune System Process Negative Regulation Of T Cell Differentiation Regulation Of Type 2 Immune Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Interferon-gamma Production Positive Regulation Of JAK-STAT Cascade Regulation Of Immune System Process Defense Response	Response To Type III Interferon Regulation Of Defense Response To Virus By Host Mucosal Immune Response Regulation Of Defense Response To Virus Defense Response To Virus
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