IFNLR1 and CTXN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IFNLR1	CTXN3
Description		interferon lambda receptor 1	cortexin 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Interleukin-28 Receptor Complex	Membrane
	Molecular Function	Cytokine Receptor Activity Protein Binding	Protein Binding
	Biological Process	Mucosal Immune Response Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Type III Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus By Host Defense Response To Virus Cellular Response To Virus Positive Regulation Of Cellular Respiration
Pathways		Other interleukin signaling Interleukin-20 family signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory skin disease ( 25574825) Molybdenum levels ( 26025379) Psoriasis vulgaris ( 26626624)	Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		7 interacting genes: ANKRD46 BRICD5 CTXN3 IFNL1 IFNL2 LSM8 PAEP	59 interacting genes: ADGRG3 AQP6 AQP9 ATP1B3 BIK BTN2A1 CD300E CD53 CD79A CERS4 CLDN14 CLEC17A CLEC7A CLRN1 COQ9 CPLX4 CREB3L1 CTLA4 EDA ERGIC3 FAM209A FFAR3 FUT7 GJA8 GJB1 GJB5 GPR152 GPR42 GPR61 IFNLR1 KASH5 KIR3DL3 KLRC1 LAPTM4B LDLRAD1 LHFPL5 LSMEM2 MFF MGST2 MTIF3 NCAPH2 OPRD1 OPRM1 PACC1 PLPP5 PVR SCN3B SLC10A2 SPACA1 STOM TLCD4 TM4SF19 TMEM106C TMEM167B TMEM179B TMEM31 TMPRSS2 TMX2 TSPAN12
Entrez ID		163702	613212
HPRD ID		09589	18888
Ensembl ID		ENSG00000185436	ENSG00000205279
Uniprot IDs		Q8IU57	Q4LDR2
PDB IDs		3OG4 3OG6 5IXD 5IXI 5L04 5T5W 9BPU 9BPV
Enriched GO Terms of Interacting Partners?		Type III Interferon-mediated Signaling Pathway Negative Regulation Of Sperm Capacitation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Interleukin-28 Receptor Binding Negative Regulation Of Memory T Cell Differentiation Interleukin-28 Receptor Complex Regulation Of Sperm Capacitation Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of MHC Class I Biosynthetic Process Lsm2-8 Complex Negative Regulation Of Interleukin-13 Production Regulation Of MHC Class I Biosynthetic Process Cytokine Activity Negative Regulation Of Interleukin-5 Production U6 SnRNP Negative Regulation Of Cell Development Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production U6 SnRNA Binding Regulation Of Memory T Cell Differentiation Defense Response To Virus Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Type 2 Immune Response	Membrane Plasma Membrane Protein Binding PH-gated Chloride Channel Activity Connexin Complex Gap Junction Channel Activity Gap Junction Immune Response-activating Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Opioid Receptor Activity G Protein-coupled Receptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Opioid Receptor Signaling Pathway Immune System Process Immune Response-regulating Signaling Pathway
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