IFNLR1 and IFNL2

Number of citations of the paper that reports this interaction (PubMedID 12469119)
0

Data Source:
HPRD (in vivo)

		IFNLR1	IFNL2
Description		interferon lambda receptor 1	interferon lambda 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Interleukin-28 Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Protein Binding	Signaling Receptor Binding Cytokine Activity
	Biological Process	Mucosal Immune Response Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Type III Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus By Host Defense Response To Virus Cellular Response To Virus Positive Regulation Of Cellular Respiration	Mucosal Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Type III Interferon-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Immune Response Defense Response To Virus Cellular Response To Virus
Pathways		Other interleukin signaling Interleukin-20 family signaling	Interleukin-20 family signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory skin disease ( 25574825) Molybdenum levels ( 26025379) Psoriasis vulgaris ( 26626624)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Leukocyte telomere length ( 32109421)
Interacting Genes		7 interacting genes: ANKRD46 BRICD5 CTXN3 IFNL1 IFNL2 LSM8 PAEP	2 interacting genes: IFNLR1 IL10RB
Entrez ID		163702	282616
HPRD ID		09589	09586
Ensembl ID		ENSG00000185436	ENSG00000183709
Uniprot IDs		Q8IU57	Q8IZJ0
PDB IDs		3OG4 3OG6 5IXD 5IXI 5L04 5T5W 9BPU 9BPV
Enriched GO Terms of Interacting Partners?		Type III Interferon-mediated Signaling Pathway Negative Regulation Of Sperm Capacitation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Interleukin-28 Receptor Binding Negative Regulation Of Memory T Cell Differentiation Interleukin-28 Receptor Complex Regulation Of Sperm Capacitation Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of MHC Class I Biosynthetic Process Lsm2-8 Complex Negative Regulation Of Interleukin-13 Production Regulation Of MHC Class I Biosynthetic Process Cytokine Activity Negative Regulation Of Interleukin-5 Production U6 SnRNP Negative Regulation Of Cell Development Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production U6 SnRNA Binding Regulation Of Memory T Cell Differentiation Defense Response To Virus Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Type 2 Immune Response	Interleukin-28 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of Cellular Respiration Regulation Of Cellular Respiration Cellular Response To Virus Interferon-mediated Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Interleukin-10 Receptor Activity Defense Response To Virus Response To Type III Interferon Response To Virus Cytokine-mediated Signaling Pathway Interleukin-10-mediated Signaling Pathway Mucosal Immune Response Defense Response Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Response To Other Organism Positive Regulation Of Receptor Signaling Pathway Via STAT Immune Response Response To External Biotic Stimulus Cytokine Receptor Activity Regulation Of Defense Response To Virus By Host Organ Or Tissue Specific Immune Response Coreceptor Activity Regulation Of Defense Response To Virus Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune System Process Cell Surface Receptor Signaling Pathway
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