IFNLR1 and IFNL2

Number of citations of the paper that reports this interaction (PMID 12469119)
211

Data Source:
HPRD (in vivo)

		IFNLR1	IFNL2
Gene Name		interferon, lambda receptor 1	interferon, lambda 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Interleukin-28 Receptor Complex	Extracellular Space
	Molecular Function	Cytokine Receptor Activity Protein Binding	Cytokine Activity
	Biological Process	Mucosal Immune Response Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Regulation Of Defense Response To Virus By Host Defense Response To Virus	Mucosal Immune Response JAK-STAT Cascade Positive Regulation Of Immune Response Defense Response To Virus
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: IFNL1 IFNL2 LSM8	2 interactors: IFNLR1 IL10RB
Entrez ID		163702	282616
HPRD ID		09589	09586
Ensembl ID		ENSG00000185436	ENSG00000183709
Uniprot IDs		Q8IU57	Q45KQ8 Q8IZJ0
PDB IDs		3OG4 3OG6
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Negative Regulation Of Memory T Cell Differentiation Defense Response To Virus Response To Virus Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Immune Response Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Type 2 Immune Response Response To Other Organism Response To Biotic Stimulus Regulation Of Interleukin-5 Production Regulation Of Immune Response Mucosal Immune Response Positive Regulation Of Immune System Process Negative Regulation Of T Cell Differentiation Regulation Of Type 2 Immune Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Interferon-gamma Production Positive Regulation Of JAK-STAT Cascade Regulation Of Immune System Process Defense Response	Defense Response To Virus Response To Type III Interferon Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Response To Other Organism Response To Biotic Stimulus Regulation Of Defense Response To Virus By Host Mucosal Immune Response Immune Response Defense Response Response To External Stimulus Cellular Response To Organic Substance Regulation Of Defense Response To Virus Immune System Process Response To Organic Substance Cell Surface Receptor Signaling Pathway Response To Stress
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