MGRN1

Gene Name		mahogunin ring finger 1, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Protein Monoubiquitination Endosome To Lysosome Transport Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		12 interactors: TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2I UBE2J2 UBE2T UBE2W
Entrez ID		23295
HPRD ID		07397
Ensembl ID		ENSG00000102858
Uniprot IDs		O60291
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein K6-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Metabolic Process Protein K63-linked Ubiquitination Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chromosome Segregation Regulation Of Innate Immune Response Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Response To Hypoxia
Tagcloud ?		agouti dark date defect e3 endosomal finger fur hect includes interacts ligase machinery mahogunin melanocortin nedd4 neurodegeneration patterning pigment pleiotropic spongiform switching trafficking transgenesis tsg101 ubiquitin ubiquitinate ubiquitination unidentified