MGRN1 and UBE2G2

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		MGRN1	UBE2G2
Gene Name		mahogunin ring finger 1, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2G 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Monoubiquitination Endosome To Lysosome Transport Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2I UBE2J2 UBE2T UBE2W	37 interactors: AMFR ARL14 BIRC8 CBL CNNM3 CPOX CUL9 FARP2 HBS1L HERPUD1 KDM2A KIAA0368 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 PARK2 POLR3F RBX1 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		23295	7327
HPRD ID		07397	04387
Ensembl ID		ENSG00000102858	ENSG00000184787
Uniprot IDs		O60291	P60604
PDB IDs			2CYX 2KLY 2LXP 3H8K 4LAD
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein K6-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Metabolic Process Protein K63-linked Ubiquitination Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chromosome Segregation Regulation Of Innate Immune Response Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Response To Hypoxia	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Catabolic Process Proteolysis Cellular Protein Metabolic Process Cellular Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Cellular Response To Topologically Incorrect Protein Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Regulation Of Mitochondrial Fusion Protein Autoubiquitination Response To Stimulus Response To Unfolded Protein Regulation Of Protein Stability Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		agouti dark date defect e3 endosomal finger fur hect includes interacts ligase machinery mahogunin melanocortin nedd4 neurodegeneration patterning pigment pleiotropic spongiform switching trafficking transgenesis tsg101 ubiquitin ubiquitinate ubiquitination unidentified	alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive e3 elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring ubiquitin
Tagcloud (Difference) ?		agouti dark date defect endosomal finger fur hect includes interacts ligase machinery mahogunin melanocortin nedd4 neurodegeneration patterning pigment pleiotropic spongiform switching trafficking transgenesis tsg101 ubiquitinate ubiquitination unidentified	alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring
Tagcloud (Intersection) ?		e3 ubiquitin