PDE4D and PAFAH1B1

Number of citations of the paper that reports this interaction (PMID 21652625)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PDE4D	PAFAH1B1
Gene Name		phosphodiesterase 4D, cAMP-specific	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Centrosome Cytosol Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane Myofibril Calcium Channel Complex	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Kinesin Complex Microtubule Associated Complex Cell Cortex Axon Growth Cone Cell Leading Edge Motile Primary Cilium Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Drug Binding SH3 Domain Binding Enzyme Binding CAMP Binding Ubiquitin Protein Ligase Binding Beta-2 Adrenergic Receptor Binding Ion Channel Binding Metal Ion Binding ATPase Binding Scaffold Protein Binding	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Protein Homodimerization Activity Phospholipase Binding Dynein Binding Dynein Intermediate Chain Binding Phosphoprotein Binding
	Biological Process	Regulation Of Heart Rate CAMP Catabolic Process Smooth Muscle Contraction Aging Memory Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Receptor Activity Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Smooth Muscle Cell Migration CAMP-mediated Signaling Lung Development Neutrophil Chemotaxis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organism Growth Cellular Protein Complex Assembly Negative Regulation Of Heart Contraction Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Endothelial Barrier Cellular Response To Lipopolysaccharide Cellular Response To CAMP Cellular Response To Epinephrine Stimulus Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Relaxation Of Cardiac Muscle	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Organelle Organization Microtubule-based Process Mitotic Nuclear Division Nuclear Migration Synaptic Transmission Neuroblast Proliferation Learning Or Memory Retrograde Axon Cargo Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Regulation Of Rho GTPase Activity Osteoclast Development Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Nuclear Envelope Disassembly Establishment Of Centrosome Localization
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events	Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs		Adenosine monophosphate Dyphylline Ketotifen Iloprost Roflumilast Piclamilast 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Ibudilast (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-ISOBUTYL-1-METHYLXANTHINE 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Asthma ( 19426955) Breast cancer ( 23535729) Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22610502) Neuroticism ( 17667963) Obesity-related traits ( 23251661) Response to antipsychotic treatment ( 23241943) Sleepiness ( 17903308)
Protein-Protein Interactions		25 interactors: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FYN GNB2L1 GOLGA8EP GOLGA8F GRB2 GSK3B LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3CA PRKACA SPTBN1 SRC TRAF1	22 interactors: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DISC1 DNAI1 HSPH1 KARS KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		5144	5048
HPRD ID		02530	03329
Ensembl ID		ENSG00000113448	ENSG00000007168
Uniprot IDs		Q08499	P43034
PDB IDs		1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Hemostasis Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Body Fluid Levels Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cellular Component Organization Cell Activation Response To Fibroblast Growth Factor Positive Regulation Of Protein Metabolic Process Response To Wounding Locomotion Regulation Of Cellular Ketone Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorylation Axonogenesis Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Axon Development Negative Regulation Of Signal Transduction Axon Guidance Innate Immune Response Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Apoptotic Process Phagocytosis Movement Of Cell Or Subcellular Component Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Protein Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuron Projection Morphogenesis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cell Death	Microtubule-based Process Microtubule Cytoskeleton Organization Mitotic Cell Cycle Process Mitotic Nuclear Division Mitotic Cell Cycle Nervous System Development Neuron Migration Cell Cycle Process Movement Of Cell Or Subcellular Component Cytoskeleton Organization Regulation Of Neuron Projection Development Generation Of Neurons Organelle Localization Neurogenesis Microtubule Bundle Formation Cytoskeleton-dependent Intracellular Transport Cell Cycle Multicellular Organismal Development Regulation Of Cell Projection Organization System Development Establishment Of Organelle Localization Regulation Of Neuron Differentiation Organelle Organization Developmental Process Central Nervous System Development Anatomical Structure Development Regulation Of Neurogenesis Cellular Localization Brain Development G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Cell Projection Organization Head Development Cell Migration Microtubule-based Movement Regulation Of Cell Development Dendrite Development Locomotion Establishment Of Chromosome Localization Cell Motility Cell Differentiation Cerebral Cortex Development Organelle Transport Along Microtubule Neuron Projection Extension Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Establishment Of Vesicle Localization Mitotic Centrosome Separation Microtubule Severing
Tagcloud ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4a phosphodiesterase select splicing xrn2	acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive lis1 lissencephaly migration neuronal null olfactory participates phenotypes soon thought understand
Tagcloud (Difference) ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4a phosphodiesterase select splicing xrn2	acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive lis1 lissencephaly migration neuronal null olfactory participates phenotypes soon thought understand
Tagcloud (Intersection) ?