SNX13 and KLF15

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SNX13	KLF15
Description		sorting nexin 13	KLF transcription factor 15
Image
GO Annotations	Cellular Component	Endosome Early Endosome Membrane Early Endosome Membrane	Chromatin Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Intracellular Protein Transport Negative Regulation Of Signal Transduction Protein Transport Positive Regulation Of GTPase Activity	Intracellular Glucose Homeostasis Regulation Of Transcription By RNA Polymerase II Glial Cell Differentiation Regulation Of Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Wnt Signaling Pathway Response To Insulin Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Negative Regulation Of Transforming Growth Factor Beta Production Podocyte Differentiation Cellular Response To Endothelin Negative Regulation Of Peptidyl-lysine Acetylation
Pathways			BMAL1:CLOCK,NPAS2 activates circadian expression
Drugs
Diseases
GWAS		Adiponectin levels ( 31178129) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Chronic widespread musculoskeletal pain ( 33331911) Creatine kinase levels ( 29403010) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 30275531 24097068) HDL cholesterol levels ( 30698716 28334899 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Lactate dehydrogenase levels ( 29403010) LDL cholesterol levels x long total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Metabolic syndrome ( 31589552) Neutrophil count ( 32888494) Parkinson's disease progression (composite) ( 33111402) Severe influenza A (H1N1) infection ( 26379185) Tea consumption ( 31046077) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Macular telangiectasia type 2 ( 28250457) Male-pattern baldness ( 28196072) Manganese levels ( 26025379) Metabolite levels ( 23378610) Refractive error ( 32231278) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: G6PC1 GNAS KLF15 NR1I3 TDP2	24 interacting genes: AIRIM ANKS1A APPL1 BANP C11orf68 CCDC57 CRK DVL3 HNRNPF KBTBD7 NFYC NRF1 PIK3R3 POLR1C PRKAB2 SCNM1 SHFL SNX13 STAT3 SUV39H1 TCF21 ZBTB24 ZNF330 ZNF76
Entrez ID		23161	28999
HPRD ID		09418	07568
Ensembl ID		ENSG00000071189	ENSG00000163884
Uniprot IDs		B3KN60 Q86XC4 Q9NSH0 Q9Y5W8	Q9UIH9
PDB IDs		7WF6	2ENT
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Response To Peptide Hormone Cellular Response To Hormone Stimulus 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Response To Hormone Carbohydrate Homeostasis Glucose Homeostasis Response To Resveratrol Glucose-6-phosphatase Activity Cellular Response To Oxygen-containing Compound Response To Insulin Chemical Homeostasis Glucose-6-phosphate Transport Hair Follicle Placode Formation Mu-type Opioid Receptor Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase Regulator Activity Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Developmental Growth Glycogen Catabolic Process Urate Metabolic Process Response To Stilbenoid Phosphotransferase Activity, Alcohol Group As Acceptor Phosphate Ion Binding Response To Stress Glucose 6-phosphate Metabolic Process Homeostatic Process Regulation Of Metabolic Process Response To Caloric Restriction Cellular Response To Acidic PH Guanyl Nucleotide Binding Vascular Endothelial Cell Response To Fluid Shear Stress Response To Catecholamine Renal Water Homeostasis G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Lyase Activity Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Skeletal Muscle Contraction Positive Regulation Of Adenylate Cyclase Activity
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