ZNF581 and DOCK8

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ZNF581	DOCK8
Gene Name		zinc finger protein 581	dedicator of cytokinesis 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytosol Membrane Cell Leading Edge
	Molecular Function	DNA Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: APP BANP CALCOCO2 CCDC136 CCNDBP1 DAZAP2 DOCK8 FSD2 GOLGA2 GOPC HMBOX1 HNRNPC IKZF1 KDM1A KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 LNX1 LZTS2 MDFI MTUS2 NOTCH2NL PDE4DIP PLSCR1 PNMA1 RBPMS SDCBP2 SOX5 SPERT SUV39H1 TMCC2 TRAF1 TRAF4 TRIM23 TRIM27	25 interactors: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 LRCH1 LRCH3 MED30 MEOX2 MRPL38 MTG1 RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581
Entrez ID		51545	81704
HPRD ID		15858	10920
Ensembl ID		ENSG00000171425	ENSG00000107099
Uniprot IDs		Q9P0T4	E2J6M5 E2J6M6 Q8NF50
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Binding Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Cytoplasmic Sequestering Of Protein Negative Regulation Of Gene Expression Chromatin Modification Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Protein Complex Assembly RNA Biosynthetic Process Developmental Process Chromatin Organization Regulation Of Gene Expression Negative Regulation Of Protein Transport Negative Regulation Of DNA Binding Regulation Of Transcription, DNA-templated Blood Coagulation Positive Regulation Of Neutrophil Differentiation Regulation Of Primitive Erythrocyte Differentiation Cytoplasmic Sequestering Of CFTR Protein Memory T Cell Proliferation Hemostasis Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Localization To Nucleus Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Localization Regulation Of RNA Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Negative Regulation Of Protein Binding Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Regulation Of Intracellular Protein Transport Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Viral Process Regulation Of Catalytic Activity	Regulation Of Cell Morphogenesis Regulation Of Cell Projection Assembly Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Anatomical Structure Morphogenesis Posttranscriptional Regulation Of Gene Expression Ribosome Biogenesis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Centriole Elongation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Lipid Kinase Activity Anatomical Structure Formation Involved In Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Replication Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Projection Organization Cell Projection Assembly Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Hair Follicle Cell Proliferation Actin Filament-based Process T Cell Costimulation Positive Regulation Of Cellular Component Biogenesis Ribonucleoprotein Complex Biogenesis Embryonic Pattern Specification Regulation Of Protein Complex Assembly Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Engulfment Of Apoptotic Cell Submandibular Salivary Gland Formation Actin Filament Branching Zygotic Specification Of Dorsal/ventral Axis Regulation Of Small GTPase Mediated Signal Transduction Anatomical Structure Development Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Mast Cell Chemotaxis Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Palate Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Mitotic Nuclear Division
Tagcloud ?			akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Difference) ?			akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Intersection) ?