ZNF581 and ETFDH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF581	ETFDH
Description		zinc finger protein 581	electron transfer flavoprotein dehydrogenase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Quinone Binding Ubiquinone Binding Flavin Adenine Dinucleotide Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Response To Oxidative Stress Electron Transport Chain Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways			Respiratory electron transport
Drugs			Metformin 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
Diseases			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS			Metabolic traits ( 21886157) Metabolite levels ( 20037589 31628463) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		94 interacting genes: AP2M1 APOBEC3C APP ASB13 ATG9A BANP BOLA2 BOLA2B CALCOCO2 CARD10 CBY2 CCDC136 CCNDBP1 CHURC1 CNFN CYSRT1 DAZAP2 DOCK8 DVL2 DVL3 EFEMP2 ENKD1 ETFDH FAM90A1 FANCL FHL5 FSD2 GOLGA2 GOLGA6L9 GOPC GPSM3 HMBOX1 HNRNPC HNRNPF HSF2BP IKZF1 IL16 KDM1A KHDRBS2 KRT27 KRT34 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-2 LNX1 LNX2 LZTS2 MDFI MGAT5B MTUS2 NBPF19 NID2 NOTCH2NLA NUDT22 PDE4DIP PLAGL2 PLEKHF2 PLSCR1 PNMA1 POU2AF1 PRKAB2 RBPMS RIMBP3C RSKR SDCBP2 SERTAD2 SMARCC1 SOX5 SPAG8 SPG21 SUV39H1 TEKT4 TMCC2 TRAF1 TRAF4 TRIM23 TRIM27 TRIM55 TRIM63 TRIP6 WWOX ZNF765 ZNF792	8 interacting genes: GSC2 HSD17B10 KRTAP11-1 KRTAP13-2 MYH7B OTX1 TRIM69 ZNF581
Entrez ID		51545	2110
HPRD ID		15858	01978
Ensembl ID		ENSG00000171425	ENSG00000171503
Uniprot IDs		Q9P0T4	B4DEQ0 Q16134
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Protein Binding CD4 Receptor Binding Transcription Coactivator Activity	Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Diencephalon Morphogenesis Chloride:proton Antiporter Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Metencephalon Development Keratin Filament Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity Isoleucine Metabolic Process L-isoleucine Catabolic Process Mitochondrial RNA 5'-end Processing (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of CAMKK-AMPK Signaling Cascade Intermediate Filament Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Cardiac Myofibril Structural Molecule Activity DNA-binding Transcription Factor Activity TRNA 3'-end Processing
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