ANAPC11 and CCNB1

Number of citations of the paper that reports this interaction (PMID 25161877)
0

Data Source:
BioGRID (enzymatic study)

		ANAPC11	CCNB1
Gene Name		anaphase promoting complex subunit 11	cyclin B1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol	Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Patched Binding Protein Binding Protein Kinase Binding Histone Kinase Activity
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Protein Complex Assembly Mitotic Nuclear Envelope Disassembly Mitotic Metaphase Plate Congression Spermatogenesis Response To Mechanical Stimulus Negative Regulation Of Gene Expression Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Phosphorylation Tissue Regeneration Response To Drug Mitotic Spindle Stabilization Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Histone H3-S10 Phosphorylation Involved In Chromosome Condensation
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	Phosphorylation of the APC/C MASTL Facilitates Mitotic Progression Mitotic Prometaphase G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Phosphorylation of Emi1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Mitotic G1-G1/S phases Recruitment of mitotic centrosome proteins and complexes G2/M DNA replication checkpoint Condensation of Prometaphase Chromosomes E2F mediated regulation of DNA replication G2/M DNA damage checkpoint Depolymerisation of the Nuclear Lamina Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic APC/C:Cdc20 mediated degradation of Cyclin B Resolution of Sister Chromatid Cohesion E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ANAPC1 ANAPC10 ANAPC2 CAPN11 CCNB1 CDC16 CDC25A CDC34 CDH1 CUL5 FBXO5 HECW2 KIF18A MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2K UBE2S UBE2U ZAP70	54 interactors: ANAPC11 ARID4A BRCA1 CCNB1IP1 CCNF CDC20 CDC25A CDC25C CDC27 CDC6 CDK1 CDK7 CDKN1A CDKN1B CDT1 CKS2 EP300 FLNA FZR1 GADD45A GADD45B GADD45G HERC5 HIST1H1A HIST1H1B ITPR1 KAT5 MAP4 MEF2C MOK PBK PCNA PIN1 PKMYT1 PLK1 POLA1 PRC1 PSMD4 PTCH1 PTMA RAD23A RALBP1 RB1 RPA1 RUNX2 SQSTM1 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 UBE2D2 UBE3D UBQLN1
Entrez ID		51529	891
HPRD ID		12452	00454
Ensembl ID		ENSG00000141552	ENSG00000134057
Uniprot IDs		Q9NYG5	P14635 Q5TZP9
PDB IDs			2B9R 2JGZ
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteolysis Mitotic Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Catabolic Process Mitotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Cycle Process Negative Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Chromosome Segregation Cell Cycle Regulation Of Proteolysis Regulation Of Mitotic Sister Chromatid Separation Protein Metabolic Process Cell Division Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cellular Protein Catabolic Process	Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Cell Cycle Checkpoint Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Cell Division Organelle Organization Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud ?		afg3l2 arf1 calgizzarin cki dci dph2l fb1 fxyd6 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa	5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac
Tagcloud (Difference) ?		afg3l2 arf1 calgizzarin cki dci dph2l fb1 fxyd6 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa	5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac
Tagcloud (Intersection) ?