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ANAPC11 and RNF111
Number of citations of the paper that reports this interaction (PMID
22493164
)
2
Data Source:
BioGRID
(two hybrid)
ANAPC11
RNF111
Gene Name
anaphase promoting complex subunit 11
ring finger protein 111
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Nucleolus
Cytosol
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Protein Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
SUMO Polymer Binding
SMAD Binding
Ubiquitin Protein Ligase Activity
Biological Process
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Protein Ubiquitination
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Protein Polyubiquitination
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Gene Expression
Protein Ubiquitination
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Loss of Function of TGFBR1 in Cancer
Generic Transcription Pathway
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Class I MHC mediated antigen processing & presentation
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Asperger disorder (
21182207
)
Metabolite levels (
22916037
)
Protein-Protein Interactions
27 interactors:
ANAPC1
ANAPC10
ANAPC2
CAPN11
CCNB1
CDC16
CDC25A
CDC34
CDH1
CUL5
FBXO5
HECW2
KIF18A
MAK
MLKL
NKD2
PTTG1
RNF111
TRIM65
UBC
UBE2C
UBE2D1
UBE2D2
UBE2K
UBE2S
UBE2U
ZAP70
39 interactors:
ACTN3
ANAPC11
AXIN1
CREB1
CSNK2A1
CTBP1
DTX3L
EDARADD
KRTAP5-9
LCE4A
LRSAM1
MARCH7
MVP
PHF7
PML
SMAD3
SMAD6
SMAD7
SMURF2
SUMO2
TRAF5
TRIM21
TRIM8
TSG101
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2M
UBE2Q2
UBE2V1
UBE2W
Entrez ID
51529
54778
HPRD ID
12452
09318
Ensembl ID
ENSG00000141552
ENSG00000157450
Uniprot IDs
Q9NYG5
Q6ZNA4
PDB IDs
2KIZ
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination
Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteolysis
Mitotic Cell Cycle Process
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Mitotic Cell Cycle
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Protein K11-linked Ubiquitination
Catabolic Process
Mitotic Nuclear Division
Positive Regulation Of Protein Catabolic Process
Cell Cycle Process
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Cellular Protein Modification Process
Regulation Of Chromosome Segregation
Cell Cycle
Regulation Of Proteolysis
Regulation Of Mitotic Sister Chromatid Separation
Protein Metabolic Process
Cell Division
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Cellular Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Polyubiquitination
Cellular Protein Modification Process
Protein K48-linked Ubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein K11-linked Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Macromolecule Catabolic Process
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Proteolysis
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Gene Expression
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Chromosome Organization
Protein Monoubiquitination
Negative Regulation Of Biosynthetic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Metabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Catabolic Process
Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud
?
afg3l2
arf1
calgizzarin
cki
dci
dph2l
fb1
fxyd6
gif
gp96
gpr85
hhp2
kpdxm
ksp
mrps7
ohs
osteosarcomas
ought
p110
phosphoglucoisomerase
rpl13a
rpl35a
s11
sec34
skd3
subtracted
subtractive
sulphonase
tapa
Tagcloud (Difference)
?
afg3l2
arf1
calgizzarin
cki
dci
dph2l
fb1
fxyd6
gif
gp96
gpr85
hhp2
kpdxm
ksp
mrps7
ohs
osteosarcomas
ought
p110
phosphoglucoisomerase
rpl13a
rpl35a
s11
sec34
skd3
subtracted
subtractive
sulphonase
tapa
Tagcloud (Intersection)
?