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ANAPC11 and MLKL
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
ANAPC11
MLKL
Description
anaphase promoting complex subunit 11
mixed lineage kinase domain like pseudokinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Nucleolus
Cytoplasm
Cytosol
Cullin-RING Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cell Junction
Molecular Function
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin-ubiquitin Ligase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Cell Cycle
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Regulation Of Meiotic Cell Cycle
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein Branched Polyubiquitination
Cell Surface Receptor Signaling Pathway
Programmed Cell Death
Defense Response To Virus
Protein Homotrimerization
Necroptotic Process
Necroptotic Signaling Pathway
Execution Phase Of Necroptosis
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
TRP channels
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Heel bone mineral density x serum urate levels interaction (
34046847
)
Testicular germ cell tumor (
23666239
)
Interacting Genes
58 interacting genes:
ANAPC10
ANAPC2
BANP
BEND2
CAPN11
CCNB1
CDC16
CDC20
CREB5
CRYBA2
CUL5
CYSRT1
DTX2
EFEMP1
EFEMP2
FBXO5
FOXO3
FRS3
FZR1
GPANK1
H2AC4
H2BC3
H3C1
HSD3B7
IQUB
KRTAP11-1
KRTAP13-2
KRTAP19-2
KRTAP3-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
MAK
MGAT5B
MLKL
NKD2
OXER1
P4HA3
PRKAA2
PRKAB2
PTTG1
RBPMS
RNF111
SPMIP9
TCEANC
TLE5
TRIM65
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2K
UBE2L1
UBE2S
UBE2U
WWOX
ZAP70
12 interacting genes:
ANAPC11
CDK1
CEBPA
CYLD
ITCH
NDUFB7
PSMB1
RAD18
S100A10
STAMBP
THOC3
USP2
Entrez ID
51529
197259
HPRD ID
12452
08752
Ensembl ID
ENSG00000141552
ENSG00000168404
Uniprot IDs
Q9NYG5
Q8NB16
PDB IDs
2MT5
4R2Y
4UI9
5A31
5G04
5G05
5JG6
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
6TNT
8PKP
8TAR
8TAU
9GAW
2MSV
4M67
4MWI
5KNJ
5KO1
6BWK
6D74
6LK5
6LK6
6O5Z
6UX8
6ZLE
6ZPR
6ZVO
6ZZ1
7JW7
7JXU
7MON
7NM2
7NM4
7NM5
8SLZ
Enriched GO Terms of Interacting Partners
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Protein Polyubiquitination
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Protein Modification By Small Protein Conjugation
Anaphase-promoting Complex
Protein K11-linked Ubiquitination
Protein K48-linked Ubiquitination
Post-translational Protein Modification
Ubiquitin Conjugating Enzyme Activity
Modification-dependent Protein Catabolic Process
Protein Modification Process
Positive Regulation Of Ubiquitin Protein Ligase Activity
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Anaphase-promoting Complex Binding
Regulation Of Ubiquitin-protein Transferase Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Meiotic Cell Cycle
Proteasomal Protein Catabolic Process
Intermediate Filament
Macromolecule Catabolic Process
Proteolysis
Free Ubiquitin Chain Polymerization
Regulation Of Sister Chromatid Segregation
Positive Regulation Of Protein Ubiquitination
Regulation Of Mitotic Sister Chromatid Separation
Ubiquitin-protein Transferase Activity
Cell Division
Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Regulation Of Chromosome Segregation
Regulation Of Chromosome Separation
Protein Catabolic Process
Regulation Of Nuclear Division
Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Regulation Of Mitotic Metaphase/anaphase Transition
Cytosol
Cell Cycle Phase Transition
Regulation Of Post-translational Protein Modification
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Protein Branched Polyubiquitination
Ubiquitin-like Protein Transferase Activity
Regulation Of Reproductive Process
Positive Regulation Of Cell Cycle Phase Transition
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Nuclear Division
Positive Regulation Of Mitotic Sister Chromatid Separation
Post-translational Protein Modification
Protein Deubiquitination
Protein Modification By Small Protein Removal
Macromolecule Metabolic Process
Protein Modification Process
Nucleoplasm
Regulation Of Cell Cycle
K63-linked Deubiquitinase Activity
Ubiquitin-ubiquitin Ligase Activity
Positive Regulation Of Cell Cycle
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Protein Branched Polyubiquitination
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Chromosome Segregation
Proteolysis
Protein K63-linked Deubiquitination
Positive Regulation Of Chromosome Segregation
Regulation Of Necroptotic Process
Cyclin Binding
Negative Regulation Of JNK Cascade
Regulation Of Programmed Necrotic Cell Death
Protein Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Type I Interferon Production
Pronuclear Fusion
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Interleukin-18-mediated Signaling Pathway
Met1-linked Polyubiquitin Deubiquitinase Activity
Rad6-Rad18 Complex
Protein Monoubiquitination
Positive Regulation Of Cell Cycle Process
Centrosome
Mitotic DNA-templated DNA Replication
Cyclin B1-CDK1 Complex
Cyclin A1-CDK1 Complex
Cyclin A2-CDK1 Complex
Response To Vitamin B2
C/EBP Complex
Ripoptosome Assembly
Ripoptosome Assembly Involved In Necroptotic Process
AnxA2-p11 Complex
Protein Autoubiquitination
Mitotic DNA Replication
DNA Synthesis Involved In Mitotic DNA Replication
Cyclin-dependent Protein Kinase Activity
CHOP-C/EBP Complex
Protein Linear Deubiquitination
Cysteine-type Deubiquitinase Activity
Hippocampal Neuron Apoptotic Process
Ubiquitin Protein Ligase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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