ANAPC11 and CAPN11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ANAPC11	CAPN11
Description		anaphase promoting complex subunit 11	calpain 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex	Acrosomal Vesicle Cytoplasm Cytoplasmic Vesicle
	Molecular Function	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Proteolysis
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Red cell distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		58 interacting genes: ANAPC10 ANAPC2 BANP BEND2 CAPN11 CCNB1 CDC16 CDC20 CREB5 CRYBA2 CUL5 CYSRT1 DTX2 EFEMP1 EFEMP2 FBXO5 FOXO3 FRS3 FZR1 GPANK1 H2AC4 H2BC3 H3C1 HSD3B7 IQUB KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 MAK MGAT5B MLKL NKD2 OXER1 P4HA3 PRKAA2 PRKAB2 PTTG1 RBPMS RNF111 SPMIP9 TCEANC TLE5 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U WWOX ZAP70	4 interacting genes: ANAPC11 PRKAR1A UNG XRCC6
Entrez ID		51529	11131
HPRD ID		12452	05315
Ensembl ID		ENSG00000141552	ENSG00000137225
Uniprot IDs		Q9NYG5	Q9UMQ6
PDB IDs		2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein Modification By Small Protein Conjugation Anaphase-promoting Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Protein Modification Process Positive Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Cell Cycle Proteasomal Protein Catabolic Process Intermediate Filament Macromolecule Catabolic Process Proteolysis Free Ubiquitin Chain Polymerization Regulation Of Sister Chromatid Segregation Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Sister Chromatid Separation Ubiquitin-protein Transferase Activity Cell Division Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Regulation Of Chromosome Segregation Regulation Of Chromosome Separation Protein Catabolic Process Regulation Of Nuclear Division Protein Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Reproductive Process Positive Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation	Damaged DNA Binding Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Hyperosmotic Salinity Response DNA End Binding Cellular Hyperosmotic Salinity Response Nuclear Telomere Cap Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Cellular Response To Salt Stress DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex DNA Recombination CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Cellular Response To Glucagon Stimulus Base-excision Repair, AP Site Formation Via Deaminated Base Removal Single Strand Break Repair Uracil DNA N-glycosylase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Depyrimidination Cellular Hyperosmotic Response Telomeric DNA Binding Hyperosmotic Response Response To X-ray DNA Repair Regulation Of Lymphocyte Activation Cellular Response To Gamma Radiation Response To Salt Stress Cardiac Muscle Cell Proliferation CAMP Binding Protein Kinase A Catalytic Subunit Binding Response To Glucagon Negative Regulation Of Activated T Cell Proliferation Sperm Head-tail Coupling Apparatus Negative Regulation Of CAMP/PKA Signal Transduction Somatic Hypermutation Of Immunoglobulin Genes Deoxyribose Phosphate Catabolic Process Isotype Switching Base-excision Repair, AP Site Formation Ribosomal Small Subunit Binding Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Diversification Of Immune Receptors Via Somatic Mutation Deoxyribonucleotide Catabolic Process Pyrimidine Deoxyribonucleotide Catabolic Process DNA Modification
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