NCKIPSD and PKP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NCKIPSD	PKP2
Description		NCK interacting protein with SH3 domain	plakophilin 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Intermediate Filament Plasma Membrane COP9 Signalosome Postsynapse Glutamatergic Synapse	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cell Tip Anchoring Junction
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Arp2/3 Complex Binding	DNA Binding Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Endocytosis Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Regulation Of Postsynapse Assembly	Desmosome Assembly Desmosome Organization Cell Adhesion Cell-cell Signaling Heart Development Positive Regulation Of Sodium Ion Transport Regulation Of Cell-substrate Adhesion Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Protein Localization At Cell Tip Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Keratinization Formation of the cornified envelope
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		A body shape index ( 34021172) Anorexia nervosa ( 31308545) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Atrial fibrillation ( 29892015 30061737) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965 32201043) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		42 interacting genes: ABI2 AKT1 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SHANK3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C	48 interacting genes: ACTN3 AKAP9 ARMC8 BAG4 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTBP1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP EIF4ENIF1 EXOSC8 FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 RBPMS ROPN1 SMAD9 SPTA1 TEKT4 VHL VIM YWHAG
Entrez ID		51517	5318
HPRD ID		09450	04177
Ensembl ID		ENSG00000213672	ENSG00000057294
Uniprot IDs		Q9NZQ3	A0A8V8TPU9 A0AAQ5BGY2 Q99959
PDB IDs		6DEC 6DED 6DEE	3TT9
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Translational Initiation Actin Polymerization Or Depolymerization Cellular Component Assembly Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Cytoskeletal Anchor Activity Actin Filament Polymerization Protein Polymerization Regulation Of Actin Cytoskeleton Organization Lamellipodium Assembly Vesicle Membrane Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cellular Component Organization Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration SH3 Domain Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C Inhibitor Activity Cytoskeleton Organization Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Postsynapse Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Organelle Organization Scaffold Protein Binding Regulation Of Actin Filament Length Regulation Of Cell Projection Organization Protein-containing Complex Assembly Dendritic Spine Regulation Of Cellular Component Size Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress ERBB Signaling Pathway Positive Regulation Of Translation Insulin Receptor Signaling Pathway	Desmosome Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cytoskeleton Organization Cornified Envelope Regulation Of Cardiac Muscle Cell Action Potential Cytoplasm Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Cytoskeleton Regulation Of Action Potential Cytosol Regulation Of Cardiac Muscle Cell Contraction Cell Junction Scaffold Protein Binding Heterotypic Cell-cell Adhesion Microtubule Organizing Center Regulation Of Striated Muscle Contraction Structural Constituent Of Cytoskeleton Regulation Of Heart Rate Cell-cell Junction Organization Organelle Organization Catenin-TCF7L2 Complex Cell-cell Junction Homotypic Cell-cell Adhesion Intracellular Protein Localization Protein Binding Intermediate Filament Organization Cellular Response To Indole-3-methanol Regulation Of Muscle System Process Nucleus Regulation Of Cardiac Muscle Contraction Microtubule Nucleation Cell-cell Adhesion Microtubule-based Process Response To Indole-3-methanol Regulation Of Muscle Contraction Anchoring Junction Fascia Adherens Adherens Junction Focal Adhesion Protein-DNA Complex Regulation Of Heart Contraction
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