NCKIPSD and PSORS1C2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NCKIPSD	PSORS1C2
Description		NCK interacting protein with SH3 domain	psoriasis susceptibility 1 candidate 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Intermediate Filament Plasma Membrane COP9 Signalosome Postsynapse Glutamatergic Synapse	Extracellular Region
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Arp2/3 Complex Binding	Protein Binding
	Biological Process	Endocytosis Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Regulation Of Postsynapse Assembly
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anorexia nervosa ( 31308545) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Broad depression or schizophrenia ( 30626913) Clostridioides difficle infection in antibiotics-users ( 33841421) Height ( 25282103 28552196) Hematology traits ( 23263863) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Metabolite levels ( 23823483) Multiple myeloma ( 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Night sleep phenotypes ( 27126917) Serum uric acid levels ( 30993211) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 21738480)
Interacting Genes		42 interacting genes: ABI2 AKT1 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SHANK3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C	27 interacting genes: AGR2 AP1B1 AP2B1 BANP CEP70 ERICH2 EVPL GUCA1C HMG20A HOMER3 LHX3 MED20 MEIS3 MYL2 MYL7 NCKIPSD PAX6 PEX19 REL RTRAF SERTAD1 SGTA SGTB TTC23 UBQLN1 UBQLN2 VASP
Entrez ID		51517	170680
HPRD ID		09450	17921
Ensembl ID		ENSG00000213672	ENSG00000204538
Uniprot IDs		Q9NZQ3	A0A1U9X9A6 Q9UIG4
PDB IDs		6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Translational Initiation Actin Polymerization Or Depolymerization Cellular Component Assembly Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Cytoskeletal Anchor Activity Actin Filament Polymerization Protein Polymerization Regulation Of Actin Cytoskeleton Organization Lamellipodium Assembly Vesicle Membrane Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cellular Component Organization Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration SH3 Domain Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C Inhibitor Activity Cytoskeleton Organization Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Postsynapse Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Organelle Organization Scaffold Protein Binding Regulation Of Actin Filament Length Regulation Of Cell Projection Organization Protein-containing Complex Assembly Dendritic Spine Regulation Of Cellular Component Size Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress ERBB Signaling Pathway Positive Regulation Of Translation Insulin Receptor Signaling Pathway	Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Clathrin Adaptor Complex A Band Cell Fate Specification Protein Targeting Identical Protein Binding ERAD Pathway Response To Endoplasmic Reticulum Stress Heart Contraction Positive Regulation Of Proteasomal Protein Catabolic Process Clathrin Binding Membrane Coat Heart Process Muscle Cell Fate Specification Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity
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