NCKIPSD and ARHGEF7

Number of citations of the paper that reports this interaction (PMID 14559906)
6

Data Source:
HPRD (in vitro, in vivo)

		NCKIPSD	ARHGEF7
Gene Name		NCK interacting protein with SH3 domain	Rho guanine nucleotide exchange factor (GEF) 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Intermediate Filament COP9 Signalosome	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Neuron Projection Neuronal Cell Body Protein Complex
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Cytoskeleton Organization Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response	Hematopoietic Progenitor Cell Differentiation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	EGFR downregulation Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Rho GTPase cycle Signaling by EGFR GPCR downstream signaling Ephrin signaling NRAGE signals death through JNK Signaling by Rho GTPases Signaling by EGFR in Cancer EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Bilirubin levels ( 19414484) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		19 interactors: ARHGEF7 BAIAP2 DIAPH2 DIAPH3 DLG4 DMRTB1 FASLG GRB2 ITGB1 KHDRBS1 MAPK3 NCK1 NCK2 PSMD9 SORBS3 STAC WAS WASL YWHAG	28 interactors: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 ERBB2IP GIT1 GIT2 LRRK2 MEOX2 NCK1 NCKIPSD PAK1 PAK2 PAK3 PPM1E PPM1F PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG
Entrez ID		51517	8874
HPRD ID		09450	05688
Ensembl ID		ENSG00000213672	ENSG00000102606
Uniprot IDs		Q9NZQ3	B7Z6G2 E9PDQ5 Q14155
PDB IDs			1BY1 1ZSG 2L3G
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Positive Regulation Of Organelle Organization Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Actin Filament Organization Regulation Of Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Organization Cytoskeleton Organization Neuron Projection Development Cell Projection Morphogenesis Regulation Of Actin Cytoskeleton Organization Cell Part Morphogenesis Positive Regulation Of Cytoskeleton Organization Chemotaxis Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Neuron Development Cell Development Cellular Component Assembly Regulation Of Signaling Cell Morphogenesis Phagocytosis Fc Receptor Signaling Pathway Neuron Differentiation Immune Response-activating Cell Surface Receptor Signaling Pathway Generation Of Neurons Cell Projection Organization Neurogenesis Immune System Process Regulation Of Signal Transduction Signal Transduction Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endocytosis Regulation Of ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Organization Protein Complex Assembly Signaling Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Signaling Cell Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cell Adhesion Regulation Of T Cell Activation Neuron Projection Morphogenesis Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Development Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Positive Regulation Of T Cell Activation Neuron Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Actin Cytoskeleton Organization Nervous System Development Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Positive Regulation Of Transferase Activity Axon Guidance Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Development
Tagcloud ?		2d 3d 4ebp1 adenocarcinomas atr atrip clearer concordant discordant egr emphasized gliomas growths gsk3alphabeta hypoxia look mek1 monolayer nfkappabetap65 normoxia phosphoprotein reflective s6 ser235 ser240 ser423 ser65 smad3 vegfr2
Tagcloud (Difference) ?		2d 3d 4ebp1 adenocarcinomas atr atrip clearer concordant discordant egr emphasized gliomas growths gsk3alphabeta hypoxia look mek1 monolayer nfkappabetap65 normoxia phosphoprotein reflective s6 ser235 ser240 ser423 ser65 smad3 vegfr2
Tagcloud (Intersection) ?