RTF2 and SPRY2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RTF2	SPRY2
Description		replication termination factor 2	sprouty RTK signaling antagonist 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Replication Fork Chromosome	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Ruffle Membrane Cell Projection Microtubule End
	Molecular Function	DNA Binding Protein Binding	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity Ubiquitin-protein Transferase Inhibitor Activity Molecular Function Inhibitor Activity
	Biological Process	Cellular Response To Hydroxyurea Regulation Of DNA Stability	Establishment Of Mitotic Spindle Orientation Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Angiogenesis Lung Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Projection Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lung Morphogenesis Lung Growth Bud Elongation Involved In Lung Branching Respiratory System Development ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor
Pathways			Spry regulation of FGF signaling EGFR downregulation
Drugs
Diseases
GWAS			Adiposity ( 21706003) Adventurousness ( 30643258) Body fat percentage ( 26833246) Central corneal thickness ( 32528159) Diastolic blood pressure ( 30224653) Fasting blood insulin (BMI interaction) ( 22581228) General risk tolerance (MTAG) ( 30643258) Height ( 25282103 31562340) Insulin-related traits (multivariate analysis) ( 32002517) Lactose tolerance test ( 31791255) Leisure-time exercise behaviour (age-stratified) ( 30102679) Medication use (drugs used in diabetes) ( 31015401) Methadone dose in opioid dependence ( 28115739) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658 22863734) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Sleep duration ( 25469926) Thrombocytopenia in coronary artery bypass surgery ( 30103242) Type 2 diabetes ( 29358691 30718926 32499647 31118516 30297969 30054458 28869590 26818947 24509480 22885922 20862305) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		5 interacting genes: PTGER4 SPRY2 UBC UBE2D2 UBE2L3	110 interacting genes: ADAMTSL4 AQP1 ATRIP BAG3 BRAF CATSPER1 CBL CBLB CBLC CHRD CHRNG CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 DSCR9 DYRK1A EIF4E2 FAIM FAM219A FBN1 FBXO7 FRS3 FXR1 FXR2 GNE GP9 GPRIN2 GRAP2 GRB2 GRN HEXIM2 HNRNPLL HOXA1 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1A LCE1B LCE1C LCE1F LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MB21D2 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 NUFIP2 OTX1 PACSIN3 PLSCR1 PRKAB2 PRKCD PRKD1 PTGER3 PTPN11 RAF1 RTF2 RUNX1T1 SDHB SEMA5B SH3KBP1 SHFL SIAH2 SPRY1 STK16 TCAF1 TMEM14B TNS2 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587
Entrez ID		51507	10253
HPRD ID		12769	03916
Ensembl ID		ENSG00000022277	ENSG00000136158
Uniprot IDs		A0A0A0MQR2 A2A2L6 B4DXL5 Q9BY42	O43597
PDB IDs			3BUM 3OB1 5HKY 5HKZ 5HL0
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity ERK1 And ERK2 Cascade Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Eosinophil Migration Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Lung Growth Negative Regulation Of Integrin Activation Prostaglandin Receptor Activity Post-translational Protein Modification Regulation Of Protein Ubiquitination Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Prostaglandin E Receptor Activity Ubiquitin-protein Transferase Inhibitor Activity MAPK Cascade Macromolecule Catabolic Process Regulation Of Post-translational Protein Modification Bud Elongation Involved In Lung Branching Microtubule End Negative Regulation Of Cellular Extravasation Ubiquitin-protein Transferase Activity Regulation Of Lens Fiber Cell Differentiation Respiratory System Development Protein Polyubiquitination Ubiquitin-protein Transferase Activator Activity Proteolysis Ubiquitin Protein Ligase Binding Regulation Of Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Hormone Stimulus Branch Elongation Of An Epithelium Protein Tag Activity Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Integrin Activation Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Axis Elongation Cellular Response To Prostaglandin E Stimulus Ubiquitin-like Protein Transferase Activity	Intermediate Filament Keratin Filament Keratinization Phosphotyrosine Residue Binding Identical Protein Binding Epidermis Development Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Binding Cytosol Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Receptor Tyrosine Kinase Binding SH3 Domain Binding Regulation Of Signal Transduction Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ESCRT II Complex ERBB Signaling Pathway Tissue Development Ubiquitin-protein Transferase Activity Regulation Of Cell Activation Regulation Of Biological Quality Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Zinc Ion Binding Ubiquitin Protein Ligase Activity
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