RTF2 and PTGER4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		RTF2	PTGER4
Description		replication termination factor 2	prostaglandin E receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Replication Fork Chromosome	Plasma Membrane Membrane
	Molecular Function	DNA Binding Protein Binding	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Cellular Response To Hydroxyurea Regulation Of DNA Stability	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways			Prostanoid ligand receptors G alpha (s) signalling events
Drugs			Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		5 interacting genes: PTGER4 SPRY2 UBC UBE2D2 UBE2L3	42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337
Entrez ID		51507	5734
HPRD ID		12769	03350
Ensembl ID		ENSG00000022277	ENSG00000171522
Uniprot IDs		A0A0A0MQR2 A2A2L6 B4DXL5 Q9BY42	A0PJF5 P35408
PDB IDs			5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity ERK1 And ERK2 Cascade Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Eosinophil Migration Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Lung Growth Negative Regulation Of Integrin Activation Prostaglandin Receptor Activity Post-translational Protein Modification Regulation Of Protein Ubiquitination Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Prostaglandin E Receptor Activity Ubiquitin-protein Transferase Inhibitor Activity MAPK Cascade Macromolecule Catabolic Process Regulation Of Post-translational Protein Modification Bud Elongation Involved In Lung Branching Microtubule End Negative Regulation Of Cellular Extravasation Ubiquitin-protein Transferase Activity Regulation Of Lens Fiber Cell Differentiation Respiratory System Development Protein Polyubiquitination Ubiquitin-protein Transferase Activator Activity Proteolysis Ubiquitin Protein Ligase Binding Regulation Of Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Hormone Stimulus Branch Elongation Of An Epithelium Protein Tag Activity Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Integrin Activation Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Axis Elongation Cellular Response To Prostaglandin E Stimulus Ubiquitin-like Protein Transferase Activity	Heme Oxidation Heme Oxygenase (decyclizing) Activity
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