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PDE6G and GRB2
Number of citations of the paper that reports this interaction (PMID
12624098
)
8
Data Source:
HPRD
(in vivo, in vitro)
PDE6G
GRB2
Gene Name
phosphodiesterase 6G, cGMP-specific, rod, gamma
growth factor receptor-bound protein 2
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Photoreceptor Disc Membrane
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endosome
Golgi Apparatus
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Vesicle Membrane
Extracellular Vesicular Exosome
Grb2-EGFR Complex
Molecular Function
Enzyme Inhibitor Activity
Protein Binding
Spectrin Binding
CGMP Binding
3',5'-cyclic-GMP Phosphodiesterase Activity
Phosphotyrosine Binding
SH3/SH2 Adaptor Activity
Epidermal Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Phosphatase Binding
Identical Protein Binding
Insulin Receptor Substrate Binding
Poly(A) RNA Binding
Ephrin Receptor Binding
Biological Process
Activation Of MAPK Activity
Visual Perception
Phototransduction, Visible Light
Metabolic Process
Rhodopsin Mediated Signaling Pathway
Regulation Of Rhodopsin Mediated Signaling Pathway
Negative Regulation Of Catalytic Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Cell-cell Signaling
Axon Guidance
Aging
Blood Coagulation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Viral Process
Platelet Activation
Positive Regulation Of Actin Filament Polymerization
T Cell Costimulation
Receptor Internalization
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of MAPK Cascade
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Anatomical Structure Formation Involved In Morphogenesis
Leukocyte Migration
Protein Heterooligomerization
Branching Involved In Labyrinthine Layer Morphogenesis
Cellular Response To Ionizing Radiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Visual phototransduction
Ca2+ pathway
The phototransduction cascade
Signaling by Wnt
Diseases associated with visual transduction
beta-catenin independent WNT signaling
Drugs
Pegademase bovine
4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases
GWAS
Protein-Protein Interactions
10 interactors:
ADRBK1
BHLHE40
DNM2
FNBP1
GNAO1
GRB2
L3MBTL3
MAPK3
SRC
TRIP10
347 interactors:
A2M
ABI3
ABI3BP
ABL1
ABL2
ADA
ADAM12
ADAM15
ADRB1
ADRB2
AEBP1
AES
AGT
AHSG
AJUBA
ALAS2
ALOX5
AMBP
ANXA2
AP4S1
APCS
APOH
APP
ARHGAP17
ARHGAP32
ARHGAP9
ARHGEF5
ASAP1
ASAP2
ATP8
AXL
B2M
BCAR1
BCL2A1
BCR
BLNK
BPGM
C1orf94
C21orf58
C21orf91
CALD1
CASC3
CASP2
CBL
CBLB
CBLC
CCL5
CD164
CD19
CD22
CD247
CD28
CD2AP
CD72
CDC42
CDKN1B
CFH
CHRM4
CHRND
CKS2
CLU
COPB1
COX6A1
CRK
CRKL
CSF1R
CSF3R
CSN2
CTAGE5
CTTN
CUTA
DAB2
DAG1
DCTN1
DCTN2
DDX17
DLGAP1
DNAJA3
DNAJB11
DNM1
DNM2
DOCK4
DPPA4
DRD3
DRD4
DTX1
ECHS1
EGF
EGFR
ELK1
ENO1
EP300
EPHA2
EPHB1
EPHB2
EPHB6
EPOR
EPS15
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESD
ESR1
ETV6
FABP1
FASLG
FGFR1
FGFR3
FH
FHOD1
FLT1
FLT3
FLT4
FN1
FRS2
FRS3
FTH1
FTL
FYN
GAB1
GAB2
GAB3
GAREM
GC
GHR
GIT1
GPANK1
GRB7
GSTK1
H1F0
HCLS1
HELZ
HIPK3
HNRNPC
HNRNPK
HOMEZ
HP
HRAS
HSPA5
HTT
IK
IKZF3
IL2RB
INCA1
INPP5D
IRS1
IRS2
IRS4
ITGA2B
ITGA6
ITGB4
ITIH4
ITK
JAK1
JAK2
KDR
KHDRBS1
KHDRBS2
KIAA1549L
KIF3A
KIT
KPNA2
KRT8
LAT
LAT2
LAX1
LCP2
LIME1
LMO2
LNX1
LY6G6F
LZTS2
MAP1A
MAP2
MAP3K1
MAP4K1
MAP4K3
MAP4K5
MAPK1
MAPK12
MAPK14
MAPK9
MED28
MERTK
MET
MICAL1
MLXIPL
MS4A2
MSI2
MST1R
MTA1
MTA3
MUC1
MYH11
MYH9
MYO18A
NADK
NAP1L5
NCKIPSD
NCL
ND4
NEU3
NFYB
NGFR
NIF3L1
NKD2
NPM1
NTRK1
NUTM2F
OCRL
PAG1
PAK1
PAK2
PAK4
PBXIP1
PDCD6IP
PDE4D
PDE6G
PDGFRB
PHACTR4
PHC2
PIK3AP1
PIK3C2B
PIK3CG
PIK3R1
PIK3R2
PLCG1
PNMA5
PNRC1
POLR1D
POLR2A
POMP
PON2
PPP3CA
PRAP1
PRKAB1
PRKAR1A
PRNP
PRR22
PRRC2A
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN22
PTPN23
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RALGPS1
RAPGEF1
RAPSN
RASA1
RBBP6
RBM33
RBP4
REL
REPS1
REPS2
RET
RHOU
RIF1
RNF10
RPS6KA1
SELL
SF3B4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D4A
SH3BP2
SH3D19
SH3KBP1
SHANK3
SHB
SHBG
SHC1
SHC2
SHC3
SHC4
SHKBP1
SIGLEC7
SIT1
SKAP1
SLC1A2
SLX1A
SNRNP200
SNTA1
SOCS1
SOCS7
SOS1
SOS2
SPRY1
SPRY2
SPTBN1
SRC
SS18
STAMBP
STK32C
STRADB
SYK
SYN1
SYNCRIP
SYNJ1
SYNJ2
SYP
TCEAL8
TCERG1
TEK
TF
TFG
TNFRSF1A
TNK2
TOM1L1
TP53BP2
TP63
TRAT1
TRIM27
TSC2
TUB
UBA1
UBA52
USP53
USP6NL
USP8
VAV1
VAV2
VAV3
VIM
WAS
WASF1
WASF2
WASL
WBP11
WDR1
WDR44
WIPF1
WIPF2
YLPM1
ZAP70
ZBTB7B
Entrez ID
5148
2885
HPRD ID
08914
00150
Ensembl ID
ENSG00000185527
ENSG00000177885
Uniprot IDs
P18545
B0LPF3
P62993
PDB IDs
3JWR
1AZE
1BM2
1BMB
1CJ1
1FHS
1FYR
1GCQ
1GFC
1GFD
1GHU
1GRI
1IO6
1JYQ
1JYR
1JYU
1QG1
1TZE
1X0N
1ZFP
2AOA
2AOB
2H46
2H5K
2HUW
2VVK
2VWF
2W0Z
3C7I
3IMD
3IMJ
3IN7
3IN8
3KFJ
3MXC
3MXY
3N7Y
3N84
3N8M
3OV1
3OVE
3S8L
3S8N
3S8O
Enriched GO Terms of Interacting Partners
?
Endocytosis
Vesicle-mediated Transport
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Receptor Internalization
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Receptor Metabolic Process
Receptor-mediated Endocytosis
Regulation Of Early Endosome To Late Endosome Transport
Neuron Projection Development
Neuron Development
Cell Development
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Neuron Differentiation
Cell Projection Organization
Platelet Activation
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Response To Insulin Stimulus
Small GTPase Mediated Signal Transduction
Immune System Process
Ras Protein Signal Transduction
Neuron Projection Morphogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Phagocytosis
Fc Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Response To Insulin
Generation Of Neurons
Innate Immune Response
Cellular Response To Peptide Hormone Stimulus
Response To Organonitrogen Compound
Cell Projection Morphogenesis
Cellular Response To Peptide
Cell Part Morphogenesis
Neurogenesis
Enzyme Linked Receptor Protein Signaling Pathway
System Development
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Apolipoprotein Binding
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
T Cell Costimulation
Axon Guidance
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Signaling
Signal Transduction
Cell Communication
Regulation Of Signaling
Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Cellular Response To Stimulus
Immune System Process
Response To Stimulus
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Regulation Of Catalytic Activity
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Immune Response
Regulation Of Phosphorus Metabolic Process
Regulation Of Immune System Process
Innate Immune Response
Fc Receptor Signaling Pathway
Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Regulation Of Protein Metabolic Process
Response To Stress
Immune Response
Positive Regulation Of Kinase Activity
Defense Response
Neurotrophin TRK Receptor Signaling Pathway
Movement Of Cell Or Subcellular Component
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Process
Neurotrophin Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Response To Organic Substance
Regulation Of MAPK Cascade
Positive Regulation Of Metabolic Process
Locomotion
Developmental Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Protein Metabolic Process
Response To Growth Factor
Cellular Response To Organic Substance
Tagcloud
?
actions
adaptor
antiapoptotic
behavior
believed
chemotactic
converting
crkii
crkl
focused
igfs
implicated
intracellularly
ir
irs
mediates
metabolism
mitogenic
nucleus
occur
organogenesis
outlines
promoting
shc
signalling
signals
stimulating
substrate
transmitting
Tagcloud (Difference)
?
actions
adaptor
antiapoptotic
behavior
believed
chemotactic
converting
crkii
crkl
focused
igfs
implicated
intracellularly
ir
irs
mediates
metabolism
mitogenic
nucleus
occur
organogenesis
outlines
promoting
shc
signalling
signals
stimulating
substrate
transmitting
Tagcloud (Intersection)
?