RNF138 and UBE2K

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RNF138	UBE2K
Description		ring finger protein 138	ubiquitin conjugating enzyme E2 K
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Site Of Double-strand Break	Nucleus Cytoplasm Cytosol Filopodium Tip
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Wnt Signaling Pathway Protein Ubiquitination Cellular Response To Leukemia Inhibitory Factor	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)
Interacting Genes		18 interacting genes: APP CFAP206 EFEMP2 H3C1 LNX2 NTAQ1 PCBP4 QKI RAD51D TAF9 TCF7L2 TP53 TRIM8 UBC UBE2D2 UBE2D4 UBE2K UBE2W	98 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 CEBPA DDI1 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF213 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM13 TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM6 TRIM63 TSN UBA1 UBA5 UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384
Entrez ID		51444	3093
HPRD ID		11508	04165
Ensembl ID		ENSG00000134758	ENSG00000078140
Uniprot IDs		A0A140VJT9 Q8WVD3	B3KSH4 B4DIZ2 P61086
PDB IDs			1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7 7MYF 7MYH 7OJX
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Macromolecule Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Nucleus Regulation Of MiRNA Metabolic Process Post-translational Protein Modification Protein K48-linked Ubiquitination PML Body Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Small Molecule Metabolic Process Molecular Function Activator Activity MRNA 3'-UTR Binding Protein Heterodimerization Activity Replication Fork Chromosome Organization Regulation Of Protein Localization To Nucleus Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Protein Modification Process Regulation Of RNA Splicing Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Protein K11-linked Ubiquitination Protein-N-terminal Glutamine Amidohydrolase Activity A Axonemal Microtubule Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression, Epigenetic PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Epigenetic Regulation Of Gene Expression Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Endosome To Plasma Membrane Transport Vesicle	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Modification Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Transferase Activity Zinc Ion Binding Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Catabolic Process Proteolysis Catabolic Process Protein Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Regulation Of Signaling Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Stress Identical Protein Binding Protein K6-linked Ubiquitination Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Innate Immune Response Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction SUMO Transferase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
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