RNF138 and UBE2W

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		RNF138	UBE2W
Gene Name		ring finger protein 138, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2W (putative)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm
	Molecular Function	Zinc Ion Binding Ligase Activity Protein Kinase Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Wnt Signaling Pathway Protein Ubiquitination	DNA Repair Protein Monoubiquitination Misfolded Or Incompletely Synthesized Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: APP C6orf165 LEF1 LNX2 PCBP4 QKI TAF9 TCF4 TRIM8 UBE2D2 UBE2D4 UBE2K UBE2W	69 interactors: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MARCH3 MARCH5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF185 RNF2 RNF26 RNF4 RNF5 RNF8 ROPN1 STUB1 TOPORS TRIM17 TRIM2 TRIM27 TRIM31 TRIM35 TRIM39 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4
Entrez ID		51444	55284
HPRD ID		11508	07724
Ensembl ID		ENSG00000134758	ENSG00000104343
Uniprot IDs		Q8WVD3	Q96B02 Q96FI0
PDB IDs			2A7L
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Regulation Of Protein Binding Protein K11-linked Ubiquitination Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Protein Metabolic Process Regulation Of Growth Face Morphogenesis Head Morphogenesis Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Binding Histone H3 Acetylation Response To Stress Face Development Positive Regulation Of Stem Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Body Morphogenesis Cellular Response To Stress Positive Regulation Of Gene Expression Muscle Cell Differentiation Regulation Of Viral Transcription Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Diencephalon Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway 3'-UTR-mediated MRNA Destabilization Synaptic Growth At Neuromuscular Junction Negative Regulation Of Apoptotic Process In Bone Marrow Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Forebrain Development Posttranscriptional Regulation Of Gene Expression Odontogenesis Of Dentin-containing Tooth Regulation Of Cellular Protein Metabolic Process Histone Acetylation Positive Regulation Of Cell Growth Ubiquitin-dependent Protein Catabolic Process Internal Peptidyl-lysine Acetylation Muscle Structure Development Cellular Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Neutrophil Differentiation	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Metabolic Process Cellular Response To Stress Catabolic Process Protein Monoubiquitination Response To Stress Cellular Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Viral Release From Host Cell Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell DNA Repair Negative Regulation Of Viral Transcription Proteolysis Apoptotic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Viral Transcription Programmed Cell Death Negative Regulation Of Viral Process Regulation Of Viral Process Cell Death Death Positive Regulation Of Organelle Organization Genetic Imprinting Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Histone Methylation Histone Ubiquitination Cellular Response To Stimulus
Tagcloud ?		20s aggravates bag6 d139e dnajb1 ef1a foetal hsp70s map1a map1b mesencephalic microtubule multifunctional neurones neuroprotection nigra ohda opn osteopontin pleiotrophin pull rgd sgtalpha sn substantia surviving utilised y165a yth	advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Difference) ?		20s aggravates bag6 d139e dnajb1 ef1a foetal hsp70s map1a map1b mesencephalic microtubule multifunctional neurones neuroprotection nigra ohda opn osteopontin pleiotrophin pull rgd sgtalpha sn substantia surviving utilised y165a yth	advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Intersection) ?