PDC and ADRBK1

Number of citations of the paper that reports this interaction (PMID 10884381)
7

Data Source:
HPRD (in vitro)

		PDC	ADRBK1
Gene Name		phosducin	adrenergic, beta, receptor kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytosol	Cytoplasm Cytosol Plasma Membrane Membrane Primary Cilium
	Molecular Function	Phospholipase Inhibitor Activity	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction Negative Regulation Of Catalytic Activity	Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Receptor Internalization Positive Regulation Of Catecholamine Secretion Termination Of G-protein Coupled Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Striated Muscle Contraction Neurotrophin TRK Receptor Signaling Pathway Cardiac Muscle Contraction
Pathways			G alpha (q) signalling events Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Hedgehog 'on' state Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Calmodulin induced events Downstream signal transduction PLC-gamma1 signalling Signaling by Hedgehog Signaling by EGFR in Cancer Activation of SMO
Drugs			Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ADRBK1 CAMK2A CRX EIF3I PRKACA PSMC5 YWHAZ	47 interactors: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB1 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2
Entrez ID		5132	156
HPRD ID		01373	00182
Ensembl ID		ENSG00000116703	ENSG00000173020
Uniprot IDs		P20941 Q52LP8	P25098
PDB IDs			1BAK 3CIK 3KRW 3KRX 3V5W
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation Positive Regulation Of Transport Regulation Of The Force Of Heart Contraction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Peptidyl-threonine Phosphorylation Apoptotic Process Activation Of Phospholipase C Activity Programmed Cell Death Regulation Of Cellular Localization Immune System Process Positive Regulation Of Phospholipase C Activity Cell Death Death Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Phospholipase Activity Immune Response Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Positive Regulation Of Lipase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Photoreceptor Cell Differentiation Defense Response Regulation Of Cell Cycle Arrest Regulation Of Apoptotic Process Regulation Of Cell Death Histone H3-T6 Phosphorylation Regulation Of Secretion Regulation Of Signaling Mitotic Cell Cycle Process Mitochondrial Transport Regulation Of Muscle Contraction G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Response To Stress Gene Expression Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Inclusion Body Assembly Golgi Reassembly Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transport Response To Fibroblast Growth Factor	Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Communication Signaling Platelet Activation Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To External Stimulus Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Metabolic Process Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Cell Activation Regulation Of Body Fluid Levels Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Wound Healing Cellular Calcium Ion Homeostasis Regulation Of Metabolic Process Calcium Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase Activity Response To Wounding
Tagcloud ?		ascorbate aspartate concerns dicarboxylic dopamine dopaminergic excitotoxicity extracellular glutamate microdialysis mm mpp neurone neurotoxic neurotoxicity output perfused perfusion perfusions phenyl phenylpyridinium protected protective pyrrolidine separated striatal terminals tetrahydropyridine uptake	adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites
Tagcloud (Difference) ?		ascorbate aspartate concerns dicarboxylic dopamine dopaminergic excitotoxicity extracellular glutamate microdialysis mm mpp neurone neurotoxic neurotoxicity output perfused perfusion perfusions phenyl phenylpyridinium protected protective pyrrolidine separated striatal terminals tetrahydropyridine uptake	adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites
Tagcloud (Intersection) ?