PDC and CAMK2A

Number of citations of the paper that reports this interaction (PMID 11331285)
10

Data Source:
HPRD (in vivo)

		PDC	CAMK2A
Gene Name		phosducin	calcium/calmodulin-dependent protein kinase II alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytosol	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane
	Molecular Function	Phospholipase Inhibitor Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction Negative Regulation Of Catalytic Activity	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways			Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: ADRBK1 CAMK2A CRX EIF3I PRKACA PSMC5 YWHAZ	40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		5132	815
HPRD ID		01373	06532
Ensembl ID		ENSG00000116703	ENSG00000070808
Uniprot IDs		P20941 Q52LP8	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs			2VZ6 3SOA
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation Positive Regulation Of Transport Regulation Of The Force Of Heart Contraction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Peptidyl-threonine Phosphorylation Apoptotic Process Activation Of Phospholipase C Activity Programmed Cell Death Regulation Of Cellular Localization Immune System Process Positive Regulation Of Phospholipase C Activity Cell Death Death Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Phospholipase Activity Immune Response Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Positive Regulation Of Lipase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Photoreceptor Cell Differentiation Defense Response Regulation Of Cell Cycle Arrest Regulation Of Apoptotic Process Regulation Of Cell Death Histone H3-T6 Phosphorylation Regulation Of Secretion Regulation Of Signaling Mitotic Cell Cycle Process Mitochondrial Transport Regulation Of Muscle Contraction G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Response To Stress Gene Expression Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Inclusion Body Assembly Golgi Reassembly Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transport Response To Fibroblast Growth Factor	Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential
Tagcloud ?		ascorbate aspartate concerns dicarboxylic dopamine dopaminergic excitotoxicity extracellular glutamate microdialysis mm mpp neurone neurotoxic neurotoxicity output perfused perfusion perfusions phenyl phenylpyridinium protected protective pyrrolidine separated striatal terminals tetrahydropyridine uptake	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Difference) ?		ascorbate aspartate concerns dicarboxylic dopamine dopaminergic excitotoxicity extracellular glutamate microdialysis mm mpp neurone neurotoxic neurotoxicity output perfused perfusion perfusions phenyl phenylpyridinium protected protective pyrrolidine separated striatal terminals tetrahydropyridine uptake	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Intersection) ?