TLR8 and BTK

Number of citations of the paper that reports this interaction (PMID 12724322)
49

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TLR8	BTK
Gene Name		toll-like receptor 8	Bruton agammaglobulinemia tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Endolysosome Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Mast Cell Granule Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Receptor Activity Drug Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Microglial Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Immunoglobulin Mediated Immune Response Toll-like Receptor 8 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Regulation Of Cytokine Secretion Defense Response To Virus Cellular Response To Mechanical Stimulus	Toll-like Receptor Signaling Pathway Adaptive Immune Response Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Calcium-mediated Signaling Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway B Cell Activation Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of B Cell Differentiation Cell Maturation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway
Pathways		Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades Toll Like Receptor 7/8 (TLR7/8) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade Innate Immune System	Signaling by the B Cell Receptor (BCR) DAP12 interactions Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MyD88:Mal cascade initiated on plasma membrane FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Celiac disease ( 20190752)
Protein-Protein Interactions		3 interactors: BTK MYD88 UBC	64 interactors: ABL1 APP ARHGAP17 ARID3A ARRB1 BCL2L11 BLNK BMX CAV1 CBL CD19 CMTM3 DAPP1 EWSR1 FAS FASLG FYN GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MYD88 PIK3AP1 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2
Entrez ID		51311	695
HPRD ID		02296	02248
Ensembl ID		ENSG00000101916	ENSG00000010671
Uniprot IDs		Q9NR97	Q06187 Q5JY90
PDB IDs		3W3G 3W3J 3W3K 3W3L 3W3M 3W3N	1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3
Enriched GO Terms of Interacting Partners?		Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Molecule Of Fungal Origin Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway Response To Fungus Regulation Of Cytokine Production Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Type I Interferon Production JNK Cascade Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Antigen Receptor-mediated Signaling Pathway Regulation Of B Cell Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Molecule Of Fungal Origin Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Stress MAPK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Leukocyte Mediated Immunity Fc Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Immune System Process Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune Response Cellular Response To Stimulus Blood Coagulation Hemostasis Cell Activation Response To Stress Defense Response Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Wound Healing Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Intracellular Signal Transduction Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Stimulus Fc Receptor Signaling Pathway Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Response To Organic Substance Phosphorylation Cellular Response To Organic Substance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Metabolic Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytokine Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Activation Protein Autophosphorylation
Tagcloud ?		3m002 adaptive blotting cancerous cl075 clarify colon crc downstream il indicator innate mucosa myd88 possibility recurrence reduce serve signify stain tlr1 tlr2 tlr4 tlrs toll upregulation varied volunteers	adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction
Tagcloud (Difference) ?		3m002 adaptive blotting cancerous cl075 clarify colon crc downstream il indicator innate mucosa myd88 possibility recurrence reduce serve signify stain tlr1 tlr2 tlr4 tlrs toll upregulation varied volunteers	adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction
Tagcloud (Intersection) ?