TLR8

Gene Name		toll-like receptor 8
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Endolysosome Membrane
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Receptor Activity Drug Binding
	Biological Process	Microglial Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Immunoglobulin Mediated Immune Response Toll-like Receptor 8 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Regulation Of Cytokine Secretion Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways		Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades Toll Like Receptor 7/8 (TLR7/8) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752)
Protein-protein Interactions		3 interactors: BTK MYD88 UBC
Entrez ID		51311
HPRD ID		02296
Ensembl ID		ENSG00000101916
Uniprot IDs		Q9NR97
PDB IDs		3W3G 3W3J 3W3K 3W3L 3W3M 3W3N
Enriched GO Terms of Interacting Partners?		Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Molecule Of Fungal Origin Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway Response To Fungus Regulation Of Cytokine Production Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Type I Interferon Production JNK Cascade Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Antigen Receptor-mediated Signaling Pathway Regulation Of B Cell Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Molecule Of Fungal Origin Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Stress MAPK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Leukocyte Mediated Immunity Fc Receptor Signaling Pathway
Tagcloud ?		3m002 adaptive blotting cancerous cl075 clarify colon crc downstream il indicator innate mucosa myd88 possibility recurrence reduce serve signify stain tlr1 tlr2 tlr4 tlrs toll upregulation varied volunteers