HSD17B11 and BNIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B11	BNIP1
Description		hydroxysteroid 17-beta dehydrogenase 11	BCL2 interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Nuclear Envelope Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane COPI-coated Vesicle SNARE Complex Mitochondrial Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	SNAP Receptor Activity Protein Binding Calcium-induced Calcium Release Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Endoplasmic Reticulum Organization Response To Activity Vesicle-mediated Transport Endoplasmic Reticulum Membrane Fusion Calcium-mediated Signaling Response To Starvation Negative Regulation Of Apoptotic Process Response To Oxygen-glucose Deprivation Execution Phase Of Apoptosis Apoptotic Process In Response To Mitochondrial Fragmentation
Pathways		Estrogen biosynthesis	COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)	Glaucoma (primary open-angle) ( 29891935) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 30046033 30679814 32439900) Pulse pressure ( 30578418)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	25 interacting genes: APP BCL2 BCL2L1 CYB561 ELOVL4 ERBB2 FAM174A GPR35 HSD17B11 JAGN1 MARCHF5 NAPA NCBP1 PTGER4 RETREG3 SCN3B SLC7A14 STOM STX18 STX1A TM4SF19 TMEM31 TMX2 TSHR VMA21
Entrez ID		51170	662
HPRD ID		10881	04480
Ensembl ID		ENSG00000198189	ENSG00000113734
Uniprot IDs		Q8NBQ5	Q12981
PDB IDs		1YB1
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity	Membrane Endoplasmic Reticulum Dendritic Cell Apoptotic Process Synaptobrevin 2-SNAP-25-syntaxin-1a Complex BH3 Domain Binding Regulation Of Protein Localization Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Cellular Component Organization Regulation Of Cellular Localization Endoplasmic Reticulum Membrane Regulation Of Synaptic Vesicle Priming Regulation Of Biological Quality Cytoplasmic Vesicle Regulation Of Monoatomic Ion Transport Regulation Of Transport Negative Regulation Of Anoikis Regulation Of Membrane Potential Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization Amylin Binding Neuron Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Retinal Cell Programmed Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular PH Reduction Leukocyte Proliferation Mononuclear Cell Proliferation Myelin Sheath Regulation Of Anoikis Negative Regulation Of Calcium Ion Transmembrane Transport Apoptotic Process In Bone Marrow Cell Positive Regulation Of Protein Targeting To Membrane Regulation Of Protein Targeting To Membrane Positive Regulation Of RNA Binding Negative Regulation Of Eosinophil Extravasation SNAP Receptor Activity Presynaptic Active Zone Membrane Myosin Head/neck Binding
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