HSD17B11 and RTP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B11	RTP2
Description		hydroxysteroid 17-beta dehydrogenase 11	receptor transporter protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Plasma Membrane Cell Surface Membrane
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Protein Binding Zinc Ion Binding Olfactory Receptor Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Protein Targeting To Membrane Protein Insertion Into Membrane
Pathways		Estrogen biosynthesis	Expression and translocation of olfactory receptors
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)	Asthma ( 31959851) Basophil count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Skin pigmentation ( 28300201)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	77 interacting genes: ABHD6 ANK1 ANKS6 AQP2 AQP6 ARL13B CD74 CD79A CISD2 CLDN7 CPLX4 CXorf66 EBP ELOVL4 ELOVL6 ELOVL7 ERGIC3 EVI2A EVI2B FAM174A FAM209A FAM210B FATE1 FFAR2 GET1 GJB1 GJB5 GPR101 GPR152 GPR42 GPX8 HIBADH HSD17B11 IFNGR2 JAGN1 KASH5 KCNJ6 KIR2DL3 LAMA4 LAPTM5 LEPROTL1 LIME1 MUC1 NDUFA7 NEMP1 PDZK1IP1 REEP4 RELL2 RNASEK SAR1A SCN3B SEC11C SGPL1 SLC10A1 SLC10A6 SLC14A1 SLC34A2 SLC35H1 SLC39A9 SLC61A1 SSMEM1 STOM STX1A STX2 TAS2R5 THAP4 TMEM267 TMEM31 TMEM35A TMEM51 TMEM52B TMEM86B TMEM92 TMPPE TMX2 UACA VMA21
Entrez ID		51170	344892
HPRD ID		10881	12371
Ensembl ID		ENSG00000198189	ENSG00000198471
Uniprot IDs		Q8NBQ5	Q5QGT7
PDB IDs		1YB1
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity	Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Unsaturated Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Plasma Membrane B Cell Receptor Complex Water Transmembrane Transporter Activity Water Transport Bile Acid:sodium Symporter Activity Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Transmembrane Transport Fluid Transport Very Long-chain Fatty Acid Metabolic Process Renal Water Transport
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