HSD17B11 and TVP23B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B11	TVP23B
Description		hydroxysteroid 17-beta dehydrogenase 11	trans-golgi network vesicle protein 23 homolog B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Golgi Membrane Membrane
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process	Protein Secretion Vesicle-mediated Transport
Pathways		Estrogen biosynthesis
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	25 interacting genes: ABHD6 CEP19 ERBB2 ERBB3 ERBB4 HSD17B11 MTNR1A PBX3 REEP4 SCN3B SHISA5 SLC10A1 SLC10A6 SLC35H1 SYT16 TIMMDC1 TLCD4 TMEM14B TMEM31 TMEM80 TMX2 YIPF1 YIPF2 YIPF4 YIPF6
Entrez ID		51170	51030
HPRD ID		10881	13293
Ensembl ID		ENSG00000198189	ENSG00000171928
Uniprot IDs		Q8NBQ5	J3QL63 Q9NYZ1
PDB IDs		1YB1
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity	Golgi Trans Cisterna Golgi Medial Cisterna ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Membrane ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Bile Acid:sodium Symporter Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Mitochondrial Membrane Trans-Golgi Network Receptor Complex ERBB Signaling Pathway Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Basolateral Plasma Membrane Bile Acid And Bile Salt Transport Endomembrane System Peripheral Nervous System Development Protein Tyrosine Kinase Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Posterior Compartment Specification Anterior Compartment Pattern Formation Late Endosome Membrane Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Sodium Ion Transport Cis-Golgi Network Receptor Localization To Synapse Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Positive Regulation Of Cardiac Muscle Tissue Development Central Nervous System Morphogenesis Lysobisphosphatidic Acid Metabolic Process Positive Regulation Of Epithelial Cell Proliferation
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