HSD17B11 and GIMAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B11	GIMAP1
Description		hydroxysteroid 17-beta dehydrogenase 11	GTPase, IMAP family member 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process
Pathways		Estrogen biosynthesis
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	40 interacting genes: AQP6 ARL13B BLCAP CD79A CLEC10A CPLX4 CREB3L1 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCGR2A GJA8 GPX8 HSD17B11 IL3RA JAGN1 MGST3 PTGES REEP4 RMDN3 SCN3B SLC10A6 SLC14A1 SLC18A1 SLC71A2 STOM STX1A THAP4 TM4SF19 TMEM101 TMEM14B TMEM35A TMEM45B TMEM79 TMX1 TMX2 ZDHHC15 ZFYVE27
Entrez ID		51170	170575
HPRD ID		10881	16278
Ensembl ID		ENSG00000198189	ENSG00000213203
Uniprot IDs		Q8NBQ5	A0A090N8Z4 Q8WWP7
PDB IDs		1YB1	3V70
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Glutathione Peroxidase Activity Protein Binding Disulfide Oxidoreductase Activity
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