HSD17B11 and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B11	EHHADH
Description		hydroxysteroid 17-beta dehydrogenase 11	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways		Estrogen biosynthesis	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs		Aetiocholanolone	NADH
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)	Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17
Entrez ID		51170	1962
HPRD ID		10881	06125
Ensembl ID		ENSG00000198189	ENSG00000113790
Uniprot IDs		Q8NBQ5	Q08426
PDB IDs		1YB1
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity	Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport
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