HSD17B11 and OTULINL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B11	OTULINL
Description		hydroxysteroid 17-beta dehydrogenase 11	OTU deubiquitinase with linear linkage specificity like
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Protein Binding Ubiquitin-like Protein Peptidase Activity Ubiquitin Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process	Protein Deubiquitination
Pathways		Estrogen biosynthesis
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)	Asthma ( 32296059 34103634)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	10 interacting genes: AQP6 GOLT1A HSD17B11 JAGN1 RETREG3 SLC30A8 TMEM14B TMEM31 TMEM86B TMX2
Entrez ID		51170	54491
HPRD ID		10881	07733
Ensembl ID		ENSG00000198189	ENSG00000145569
Uniprot IDs		Q8NBQ5	Q9NUU6
PDB IDs		1YB1	6DRM
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity	Endoplasmic Reticulum Insulin Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Insulin Secretion Peptide Hormone Secretion Endoplasmic Reticulum Organization Peptide Secretion D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Hormone Secretion Carbon Dioxide Transmembrane Transporter Activity Membrane Carbon Dioxide Transmembrane Transport Endoplasmic Reticulum Membrane Steroid Dehydrogenase Activity Androgen Catabolic Process Regulation Of Hormone Levels Protein Localization To Extracellular Region Granulocyte Colony-stimulating Factor Signaling Pathway Response To Monosaccharide Hormone Transport Establishment Of Protein Localization To Extracellular Region Response To Glucose Protein Secretion Amide Transport Peptide Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Zinc:proton Antiporter Activity Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Disulfide Oxidoreductase Activity Mitochondrial Membrane Hormone Metabolic Process Estrogen Biosynthetic Process Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Insulin Secretion Response To Carbohydrate Signal Release Neutrophil Differentiation Substrate Localization To Autophagosome Zinc Ion Import Across Plasma Membrane Insulin Processing Ammonium Transmembrane Transport Regulation Of Peptide Hormone Secretion Zinc Ion Import Into Organelle Golgi Cis Cisterna
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