BNIP1 and NAPA

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		BNIP1	NAPA
Description		BCL2 interacting protein 1	NSF attachment protein alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane COPI-coated Vesicle SNARE Complex Mitochondrial Membrane Intracellular Membrane-bounded Organelle	Cytosol Plasma Membrane Membrane Neuromuscular Junction Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	SNAP Receptor Activity Protein Binding Calcium-induced Calcium Release Activity	SNARE Binding Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding Protein-containing Complex Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Endoplasmic Reticulum Organization Response To Activity Vesicle-mediated Transport Endoplasmic Reticulum Membrane Fusion Calcium-mediated Signaling Response To Starvation Negative Regulation Of Apoptotic Process Response To Oxygen-glucose Deprivation Execution Phase Of Apoptosis Apoptotic Process In Response To Mitochondrial Fragmentation	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Brain Development Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Vesicle-mediated Transport Neuron Differentiation Protein-containing Complex Disassembly Synaptic Transmission, Glutamatergic SNARE Complex Disassembly Apical Protein Localization Membrane Fusion
Pathways		COPI-dependent Golgi-to-ER retrograde traffic	COPII-mediated vesicle transport Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 29891935) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 30046033 30679814 32439900) Pulse pressure ( 30578418)	Blood protein levels ( 30072576)
Interacting Genes		25 interacting genes: APP BCL2 BCL2L1 CYB561 ELOVL4 ERBB2 FAM174A GPR35 HSD17B11 JAGN1 MARCHF5 NAPA NCBP1 PTGER4 RETREG3 SCN3B SLC7A14 STOM STX18 STX1A TM4SF19 TMEM31 TMX2 TSHR VMA21	22 interacting genes: APP BNIP1 DSCAM FURIN GNA12 GOSR1 GOSR2 HSPB1 HUNK NSF RIPK4 RTN4 SNAP23 SNAP25 STX12 STX1A STX4 STX5 STX7 STX8 TRPC3 VAMP8
Entrez ID		662	8775
HPRD ID		04480	04447
Ensembl ID		ENSG00000113734	ENSG00000105402
Uniprot IDs		Q12981	P54920
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Dendritic Cell Apoptotic Process Synaptobrevin 2-SNAP-25-syntaxin-1a Complex BH3 Domain Binding Regulation Of Protein Localization Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Cellular Component Organization Regulation Of Cellular Localization Endoplasmic Reticulum Membrane Regulation Of Synaptic Vesicle Priming Regulation Of Biological Quality Cytoplasmic Vesicle Regulation Of Monoatomic Ion Transport Regulation Of Transport Negative Regulation Of Anoikis Regulation Of Membrane Potential Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization Amylin Binding Neuron Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Retinal Cell Programmed Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular PH Reduction Leukocyte Proliferation Mononuclear Cell Proliferation Myelin Sheath Regulation Of Anoikis Negative Regulation Of Calcium Ion Transmembrane Transport Apoptotic Process In Bone Marrow Cell Positive Regulation Of Protein Targeting To Membrane Regulation Of Protein Targeting To Membrane Positive Regulation Of RNA Binding Negative Regulation Of Eosinophil Extravasation SNAP Receptor Activity Presynaptic Active Zone Membrane Myosin Head/neck Binding	SNAP Receptor Activity SNARE Complex Organelle Membrane Fusion Membrane Fusion Organelle Fusion Vesicle Fusion SNARE Binding Membrane Organization Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Docking Vesicle-mediated Transport Establishment Of Localization In Cell Chloride Channel Inhibitor Activity Protein Transport Syntaxin Binding Establishment Of Protein Localization Secretion By Cell Endomembrane System Intracellular Protein Localization Organelle Localization Intracellular Transport Vesicle Neuron Projection Secretion Exocytosis Intracellular Protein Transport SNARE Complex Assembly Recycling Endosome Cellular Localization Golgi Vesicle Transport Plasma Membrane Endosome Organelle Organization Membrane Neurotransmitter Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Neuron Recognition Modulation Of Chemical Synaptic Transmission Positive Regulation Of Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of Regulated Secretory Pathway Protein-containing Complex Organization Heparan Sulfate Binding Regulation Of Protein Localization To Cell Periphery
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