BNIP1 and STX18

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		BNIP1	STX18
Description		BCL2 interacting protein 1	syntaxin 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane COPI-coated Vesicle SNARE Complex Mitochondrial Membrane Intracellular Membrane-bounded Organelle	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane SNARE Complex
	Molecular Function	SNAP Receptor Activity Protein Binding Calcium-induced Calcium Release Activity	SNAP Receptor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Endoplasmic Reticulum Organization Response To Activity Vesicle-mediated Transport Endoplasmic Reticulum Membrane Fusion Calcium-mediated Signaling Response To Starvation Negative Regulation Of Apoptotic Process Response To Oxygen-glucose Deprivation Execution Phase Of Apoptosis Apoptotic Process In Response To Mitochondrial Fragmentation	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Membrane Fusion Endoplasmic Reticulum Membrane Organization Positive Regulation Of Organelle Assembly Positive Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Golgi Organization
Pathways		COPI-dependent Golgi-to-ER retrograde traffic	COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 29891935) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 30046033 30679814 32439900) Pulse pressure ( 30578418)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Chronic rhinosinusitis ( 33393196) Congenital heart disease ( 23708191)
Interacting Genes		25 interacting genes: APP BCL2 BCL2L1 CYB561 ELOVL4 ERBB2 FAM174A GPR35 HSD17B11 JAGN1 MARCHF5 NAPA NCBP1 PTGER4 RETREG3 SCN3B SLC7A14 STOM STX18 STX1A TM4SF19 TMEM31 TMX2 TSHR VMA21	6 interacting genes: BNIP1 DISC1 LCOR NSG2 NUPR1 SNCA
Entrez ID		662	53407
HPRD ID		04480	06923
Ensembl ID		ENSG00000113734	ENSG00000168818
Uniprot IDs		Q12981	Q9P2W9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Dendritic Cell Apoptotic Process Synaptobrevin 2-SNAP-25-syntaxin-1a Complex BH3 Domain Binding Regulation Of Protein Localization Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Cellular Component Organization Regulation Of Cellular Localization Endoplasmic Reticulum Membrane Regulation Of Synaptic Vesicle Priming Regulation Of Biological Quality Cytoplasmic Vesicle Regulation Of Monoatomic Ion Transport Regulation Of Transport Negative Regulation Of Anoikis Regulation Of Membrane Potential Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization Amylin Binding Neuron Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Retinal Cell Programmed Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular PH Reduction Leukocyte Proliferation Mononuclear Cell Proliferation Myelin Sheath Regulation Of Anoikis Negative Regulation Of Calcium Ion Transmembrane Transport Apoptotic Process In Bone Marrow Cell Positive Regulation Of Protein Targeting To Membrane Regulation Of Protein Targeting To Membrane Positive Regulation Of RNA Binding Negative Regulation Of Eosinophil Extravasation SNAP Receptor Activity Presynaptic Active Zone Membrane Myosin Head/neck Binding	Regulation Of Aerobic Respiration Regulation Of Oxidative Phosphorylation Regulation Of Cellular Respiration Kinesin Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Apoptotic Process In Response To Mitochondrial Fragmentation Negative Regulation Of Serotonin Uptake Positive Regulation Of Catabolic Process Transporter Regulator Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Autophagy Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Synaptic Vesicle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Oxidative Phosphorylation Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Calcium-induced Calcium Release Activity Endoplasmic Reticulum Membrane Fusion Negative Regulation Of Dopamine Metabolic Process Molecular Adaptor Activity Cytoplasmic Vesicle Membrane Positive Regulation Of Inflammatory Response Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Perinuclear Region Of Cytoplasm Negative Regulation Of Catecholamine Metabolic Process Regulation Of Serotonin Uptake Golgi Cis Cisterna Membrane Cell Death Negative Regulation Of Programmed Cell Death Programmed Cell Death Apoptotic Process Negative Regulation Of Apoptotic Process Mitochondrial Outer Membrane Presynapse Regulation Of Chaperone-mediated Autophagy Dopamine Uptake Involved In Synaptic Transmission Response To Iron(II) Ion Calcium Ion Homeostasis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Proteolysis
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