ZNF580 and ARHGEF6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF580	ARHGEF6
Gene Name		zinc finger protein 580	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Intracellular Cytosol Cell-cell Junction Lamellipodium
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chemotaxis Inflammatory Response Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-8 Production Cellular Response To Hydrogen Peroxide	Apoptotic Process JNK Cascade Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rho GTPase Activity Cell Junction Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Cell junction organization Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G alpha (12/13) signalling events Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ARHGEF6 PAX9 RAD54B SH3GL2 TSC22D4 XBP1	22 interactors: ADAM15 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580
Entrez ID		51157	9459
HPRD ID		18353	02226
Ensembl ID		ENSG00000213015	ENSG00000129675
Uniprot IDs		Q9UK33	B7Z3C7 Q15052 Q8N4Q3
PDB IDs			1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development Response To Insulin-like Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Involved In Salivary Gland Development Cellular Response To Organic Substance Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Serotonin Secretion Neurotrophin Signaling Pathway Response To Organic Substance Positive Regulation Of Hepatocyte Proliferation Cellular Response To Fructose Stimulus Positive Regulation Of Interleukin-6 Secretion Response To Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Response To Laminar Fluid Shear Stress Serotonin Transport Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Immunoglobulin Secretion Exocrine Pancreas Development Cellular Triglyceride Homeostasis Response To Fructose Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Hepatocyte Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Negative Regulation Of Biosynthetic Process Fatty Acid Homeostasis Regulation Of Immunoglobulin Secretion Cellular Response To Fluid Shear Stress Positive Regulation Of B Cell Differentiation Response To Laminar Fluid Shear Stress Endothelial Cell Proliferation Cellular Response To Stress Cellular Response To Antibiotic Negative Regulation Of Striated Muscle Cell Differentiation Response To Stress Epithelial Cell Maturation Positive Regulation Of TOR Signaling	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Morphogenesis Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Cell Development Intracellular Signal Transduction Anatomical Structure Morphogenesis Axon Guidance Chemotaxis Signal Transduction By Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Differentiation Nervous System Development System Development Cell Morphogenesis Axonogenesis Primary MiRNA Processing Regulation Of Cellular Component Organization Axon Development Generation Of Neurons Positive Regulation Of Cell Differentiation Regulation Of Cell Development Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death SMAD Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neurogenesis Locomotion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Multicellular Organismal Development Signaling Regulation Of Signal Transduction Cell Communication Anatomical Structure Development Response To External Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Growth Positive Regulation Of Cell Development Regulation Of Cell Proliferation Heart Development Embryonic Cranial Skeleton Morphogenesis Signal Transduction
Tagcloud ?			acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Difference) ?			acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Intersection) ?