ZNF580 and XBP1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZNF580	XBP1
Gene Name		zinc finger protein 580	X-box binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Transcription Factor Binding Enhancer Sequence-specific DNA Binding Protease Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chemotaxis Inflammatory Response Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-8 Production Cellular Response To Hydrogen Peroxide	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Liver Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Immunoglobulin Production Transcription From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Phosphatidylinositol 3-kinase Signaling Cell Growth Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Positive Regulation Of Histone Methylation Regulation Of Protein Stability Protein Destabilization Cellular Response To Nutrient Positive Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cellular Triglyceride Homeostasis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Glucose Starvation Response To Drug Cholesterol Homeostasis Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Positive Regulation Of Immunoglobulin Secretion Response To Electrical Stimulus Fatty Acid Homeostasis Sterol Homeostasis Serotonin Secretion, Neurotransmission Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Antibiotic Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-6 Secretion
Pathways
Drugs
Diseases
GWAS			Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		6 interactors: ARHGEF6 PAX9 RAD54B SH3GL2 TSC22D4 XBP1	19 interactors: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1F0 H1FX HDGF NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I ZNF440 ZNF580
Entrez ID		51157	7494
HPRD ID		18353	01908
Ensembl ID		ENSG00000213015	ENSG00000100219
Uniprot IDs		Q9UK33	P17861
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development Response To Insulin-like Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Involved In Salivary Gland Development Cellular Response To Organic Substance Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Serotonin Secretion Neurotrophin Signaling Pathway Response To Organic Substance Positive Regulation Of Hepatocyte Proliferation Cellular Response To Fructose Stimulus Positive Regulation Of Interleukin-6 Secretion Response To Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Response To Laminar Fluid Shear Stress Serotonin Transport Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Immunoglobulin Secretion Exocrine Pancreas Development Cellular Triglyceride Homeostasis Response To Fructose Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Hepatocyte Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Negative Regulation Of Biosynthetic Process Fatty Acid Homeostasis Regulation Of Immunoglobulin Secretion Cellular Response To Fluid Shear Stress Positive Regulation Of B Cell Differentiation Response To Laminar Fluid Shear Stress Endothelial Cell Proliferation Cellular Response To Stress Cellular Response To Antibiotic Negative Regulation Of Striated Muscle Cell Differentiation Response To Stress Epithelial Cell Maturation Positive Regulation Of TOR Signaling	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Estrogen Receptor Signaling Pathway Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Regulation Of Cellular Process Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of SUMO Transferase Activity Positive Regulation Of Nuclease Activity Regulation Of DNA-templated Transcription In Response To Stress Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Organization Cellular Response To Organic Substance Notochord Regression
Tagcloud ?			alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced stx stx2 toxigenic toxins transcripts untreated uremic
Tagcloud (Difference) ?			alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced stx stx2 toxigenic toxins transcripts untreated uremic
Tagcloud (Intersection) ?