KMT5A and DTL

Number of citations of the paper that reports this interaction (PubMedID 20932472)
44

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		KMT5A	DTL
Description		lysine methyltransferase 5A	denticleless E3 ubiquitin protein ligase adapter
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Polytene Chromosome Cytosol	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Methyltransferase Activity Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Mitotic Chromosome Condensation Peptidyl-lysine Monomethylation Replication Fork Processing Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Cell Division Protein Localization To Chromatin Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination Translesion Synthesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle
Pathways		Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Negative Regulation of CDH1 Gene Transcription	Recognition of DNA damage by PCNA-containing replication complex Neddylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)	Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379) Plateletcrit ( 32888494)
Interacting Genes		14 interacting genes: BTRC DTL E2F2 FAM9A H4C1 H4C16 PCNA RNF168 RNF8 TCF7L2 TP53 TWIST1 UBE2I USP17L2	17 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 DDB1 KAT2A KMT5A PCNA POLD4 POLH TDG TOB1 TP53 UBE2D1 UBE2N
Entrez ID		387893	51514
HPRD ID		06254	17952
Ensembl ID		ENSG00000183955	ENSG00000143476
Uniprot IDs		E3VVS3 Q9NQR1	B4E0E6 F5GZ90 Q9NZJ0
PDB IDs		1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ 7D1Z 7D20 7XPX	6QC0
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromosome Organization Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region DNA Metabolic Process Negative Regulation Of Biosynthetic Process Response To Radiation Regulation Of DNA Repair Chromatin Organization Post-translational Protein Modification Protein K63-linked Ubiquitination Regulation Of DNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Site Of Double-strand Break DNA Damage Checkpoint Signaling Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Localization To Chromosome PML Body CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Chromatin Remodeling Lymphocyte Activation Involved In Immune Response Telomere Organization Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA Repair Translesion Synthesis Synaptonemal Complex	Regulation Of DNA Metabolic Process DNA Metabolic Process DNA Repair DNA Damage Response DNA Replication Regulation Of DNA Replication Cellular Response To Stress Negative Regulation Of Cell Cycle Process Cellular Response To UV DNA Damage Checkpoint Signaling Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cellular Response To Light Stimulus Nucleoplasm Chromatin Organization Replicative Senescence Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Repair Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Response To UV Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Chromosome, Telomeric Region Replication Fork Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA Metabolic Process G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle
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