SETD8 and E2F2

Number of citations of the paper that reports this interaction (PMID 12411495)
72

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SETD8	E2F2
Gene Name		SET domain containing (lysine methyltransferase) 8	E2F transcription factor 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Nucleoplasm Transcription Factor Complex
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Mitotic Nuclear Division Peptidyl-lysine Monomethylation Histone Lysine Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division	Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Lens Fiber Cell Apoptotic Process
Pathways		Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase	DNA Replication Pre-Initiation Cellular Senescence G1 Phase M/G1 Transition Regulation of DNA replication CDC6 association with the ORC:origin complex Oncogene Induced Senescence Cell Cycle, Mitotic Assembly of the pre-replicative complex Cyclin D associated events in G1 Oxidative Stress Induced Senescence Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: DTL E2F2 FAM9A HIST4H4 LEF1 PCNA TP53 TWIST1 UBE2I	17 interactors: ARID3A ATAD2 BCAR1 BRD2 CDK3 FHL2 GIT2 GNB5 RB1 RNF144A RYBP SETD8 SP1 SPIB TFDP1 TFDP2 YY1
Entrez ID		387893	1870
HPRD ID		06254	02692
Ensembl ID		ENSG00000183955	ENSG00000007968
Uniprot IDs		E3VVS3 Q9NQR1	Q14209
PDB IDs		1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8	1N4M
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Translesion Synthesis DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Postreplication Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction By P53 Class Mediator Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Gene Expression Negative Regulation Of Striated Muscle Tissue Development Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Neural Crest Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Muscle Organ Development Positive Regulation Of Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Epithelial To Mesenchymal Transition Base-excision Repair Chromosome Organization T Cell Activation Involved In Immune Response Neural Crest Cell Development Cell Cycle Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Epithelium Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Telomere Maintenance Neural Crest Cell Differentiation Somitogenesis Positive Regulation Of Deoxyribonuclease Activity Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Positive Regulation Of SUMO Transferase Activity	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Androgen Receptor Signaling Pathway DNA-templated Transcription, Initiation Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Chromatin Modification Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Sequestering Of Nodal From Receptor Via Nodal Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process
Tagcloud ?		5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379	accordingly acting collectively documented downregulates escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate stk40 subgroup supporting suppressive te undetectable upstream virtually
Tagcloud (Difference) ?		5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379	accordingly acting collectively documented downregulates escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate stk40 subgroup supporting suppressive te undetectable upstream virtually
Tagcloud (Intersection) ?