KMT5A and BTRC

Number of citations of the paper that reports this interaction (PubMedID 26666832)
48

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		KMT5A	BTRC
Description		lysine methyltransferase 5A	beta-transducin repeat containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Polytene Chromosome Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Methyltransferase Activity Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity	Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Mitotic Chromosome Condensation Peptidyl-lysine Monomethylation Replication Fork Processing Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Cell Division Protein Localization To Chromatin Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Lysosome Organization Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Mammary Gland Epithelial Cell Proliferation Non-canonical NF-kappaB Signal Transduction TORC1 Signaling Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Rhythmic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling
Pathways		Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Negative Regulation of CDH1 Gene Transcription	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Interleukin-1 signaling GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)	Diastolic blood pressure ( 30224653) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)
Interacting Genes		14 interacting genes: BTRC DTL E2F2 FAM9A H4C1 H4C16 PCNA RNF168 RNF8 TCF7L2 TP53 TWIST1 UBE2I USP17L2	94 interacting genes: AGO2 AKT1 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CRYAA CTNNB1 CUL1 DBN1 DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HERC3 HIPK2 HNRNPU ICE1 IKBKB IL10RA JUP KDR KEAP1 KMT5A LINC00511 LPCAT1 MAPK1 MAPK13 MAPK14 MAPK6 MAPK9 MCL1 MDM2 MITF MYB NFE2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PHF19 PLK4 PSMA3 PSMD4 RASSF5 RCAN1 RELA RIPK4 RNF7 SKP1 SLC7A11-AS1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAFAZZIN TFE3 TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 WWTR1 XRCC1 ZC3H12A
Entrez ID		387893	8945
HPRD ID		06254	04596
Ensembl ID		ENSG00000183955	ENSG00000166167
Uniprot IDs		E3VVS3 Q9NQR1	A0A0S2Z4P6 B2R8L3 B7Z3H4 Q9Y297
PDB IDs		1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ 7D1Z 7D20 7XPX	1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromosome Organization Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region DNA Metabolic Process Negative Regulation Of Biosynthetic Process Response To Radiation Regulation Of DNA Repair Chromatin Organization Post-translational Protein Modification Protein K63-linked Ubiquitination Regulation Of DNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Site Of Double-strand Break DNA Damage Checkpoint Signaling Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Localization To Chromosome PML Body CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Chromatin Remodeling Lymphocyte Activation Involved In Immune Response Telomere Organization Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA Repair Translesion Synthesis Synaptonemal Complex	Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cytosol Protein Catabolic Process Nucleus Positive Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Developmental Process Nucleoplasm Cytoplasm Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process Regulation Of Multicellular Organismal Development Response To Oxidative Stress Negative Regulation Of Cell Differentiation Protein Ubiquitination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process Macromolecule Metabolic Process
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