SETD8

Gene Name		SET domain containing (lysine methyltransferase) 8
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Mitotic Nuclear Division Peptidyl-lysine Monomethylation Histone Lysine Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division
Pathways		Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: DTL E2F2 FAM9A HIST4H4 LEF1 PCNA TP53 TWIST1 UBE2I
Entrez ID		387893
HPRD ID		06254
Ensembl ID		ENSG00000183955
Uniprot IDs		E3VVS3 Q9NQR1
PDB IDs		1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Translesion Synthesis DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Postreplication Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction By P53 Class Mediator Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Gene Expression Negative Regulation Of Striated Muscle Tissue Development Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Neural Crest Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Muscle Organ Development Positive Regulation Of Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Epithelial To Mesenchymal Transition Base-excision Repair Chromosome Organization T Cell Activation Involved In Immune Response Neural Crest Cell Development Cell Cycle Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Epithelium Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Telomere Maintenance Neural Crest Cell Differentiation Somitogenesis Positive Regulation Of Deoxyribonuclease Activity Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Positive Regulation Of SUMO Transferase Activity
Tagcloud ?		5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379