GCK and PRKN

Number of citations of the paper that reports this interaction (PubMedID 24187134)
63

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GCK	PRKN
Description		glucokinase	parkin RBR E3 ubiquitin protein ligase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Golgi Membrane Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Postsynaptic Density Membrane Aggresome Nuclear Speck SCF Ubiquitin Ligase Complex Axon Synaptic Vesicle Membrane Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Lewy Body Intracellular Vesicle Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity Glucose Sensor Activity	G Protein-coupled Receptor Binding Transcription Corepressor Activity Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Tubulin Binding Transferase Activity SH3 Domain Binding Enzyme Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Phospholipase Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding
	Biological Process	Intracellular Glucose Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Glycolytic Process Regulation Of Glycolytic Process Purine Nucleotide Metabolic Process NADP+ Metabolic Process Response To Glucose Hexose Metabolic Process Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Glucose Homeostasis Regulation Of Potassium Ion Transport Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Calcium Ion Import	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitochondrial Fission Autophagy Of Mitochondrion Mitophagy Synaptic Transmission, Dopaminergic Startle Response Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Autophagy Response To Oxidative Stress Response To Unfolded Protein Mitochondrion Organization Central Nervous System Development Learning Locomotory Behavior Adult Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Free Ubiquitin Chain Polymerization Regulation Of Dopamine Secretion Response To Muscle Activity Macroautophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Anatomical Structure Morphogenesis Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Oxidative Stress Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus ERAD Pathway Regulation Of Dopamine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein K27-linked Ubiquitination Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Protein Stabilization Response To Corticosterone Positive Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Localization Protein Autoubiquitination Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Necroptotic Process Regulation Of Canonical Wnt Signaling Pathway Type 2 Mitophagy Regulation Of Biological Quality Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Manganese Ion Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Negative Regulation Of Excitatory Postsynaptic Potential Cellular Response To Toxic Substance Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Protein Catabolic Process At Presynapse Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Secretion By Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Dendrite Extension Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Cellular Response To L-glutamine Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Cellular Response To L-glutamate Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Localization To Membrane Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of gene expression in beta cells Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PINK1-PRKN Mediated Mitophagy Regulation of necroptotic cell death Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases		Permanent neonatal diabetes mellitus (PNDM) Maturity onset diabetes of the young (MODY)	Parkinson's disease (PD)
GWAS		Birth weight ( 27680694 31043758) Blood glucose levels ( 31928498) Blood sugar levels ( 29403010) Coronary artery disease and triglyceride levels (multivariate analysis) ( 30525989) Fasting blood glucose ( 20081858 25631608 33842983 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 19060907 25187374) Fructosamine levels ( 34753797) Glycated hemoglobin levels ( 31213470 34059833 19096518 28898252 24647736 20858683 24244560) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Homeostasis model assessment of beta-cell function ( 20081858) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109 23823483) Offspring birth weight ( 31043758 29309628) Pulse pressure ( 27841878 30578418) Triglyceride levels ( 31928498 32154731 32203549) Triglycerides ( 30275531) Two-hour glucose ( 34059833) Type 2 diabetes ( 30718926 22885922 32499647 30297969)	Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		7 interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 PRKN SPDYE4	131 interacting genes: ADRM1 AIMP2 ATXN3 BAG5 BCL2L1 CASK CASP1 CASP8 CCND1 CDKN1A CHPF COMMD1 COXFA4L2 CRX CUL1 DLG1 DLX2 DNM1L DYRK1A EIF4B EPS15 FAF1 FAM120A FBP1 FBXO7 FBXW7 GATA4 GCK GPR37 GRIN2B GTPBP4 HDAC6 HEXD IKBKG LSG1 MDM2 MEOX1 MEOX2 MFN1 MFN2 MRPL13 MRPL19 MRPL45 MTOR NEDD8 NEK2 NKRF NQO1 PA2G4 PAFAH1B2 PDCD2 PHB2 PICK1 PKM PLK1 PRKAA2 PSMA1 PSMA7 PSMC1 PSMC2 PSMC5 PSMD4 PTPN5 PTTG1 RAB7A RAC1 RAD1 RAD23A RALY RANBP2 RBCK1 REL RFFL RGS2 RGS3 RHOT2 SEPTIN4 SEPTIN5 SF3B2 SF3B3 SIM2 SNCA SNCAIP SRSF1 STUB1 SUMO1 SYT11 TCF4 TENT5C TOMM40 TOMM70 TP53 TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2R2 UBE2S UBE2T UBE2V1 UBE2Z USP30 USP33 VDAC1 VDR YWHAH ZNF622 ZNF746
Entrez ID		2645	5071
HPRD ID		00680	03967
Ensembl ID		ENSG00000106633	ENSG00000185345
Uniprot IDs		A0A5F9ZGW4 H7BXV0 P35557 Q53Y25	O60260 X5DR79
PDB IDs		1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I 7T78 7T79	1IYF 2JMO 4BM9 4I1F 4I1H 5C1Z 5C23 5C9V 5N2W 5N38 5TR5 6GLC 6HUE 6N13 8IK6 8IKV 8JWV 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glucokinase Activity 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Fructose Metabolic Process Glucose Metabolic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Response To L-glutamate Positive Regulation Of Mitochondrial Fission Carbohydrate Phosphorylation Hexose Metabolic Process Monosaccharide Metabolic Process Regulation Of Catalytic Activity Regulation Of Secretion By Cell Regulation Of Mitochondrial Fission Regulation Of Peptide Hormone Secretion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Secretion Positive Regulation Of ATP Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Glycolytic Process ADP Catabolic Process Gluconeogenesis Purine Ribonucleoside Diphosphate Catabolic Process Positive Regulation Of Secretion By Cell ADP Metabolic Process Hexose Biosynthetic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Pyruvate Metabolic Process Negative Regulation Of Spontaneous Neurotransmitter Secretion PCNA Complex Replisome Negative Regulation Of Protein Secretion Regulation Of ATP Metabolic Process Negative Regulation Of Kinase Activity Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process	Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Macromolecule Catabolic Process Cytosol Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Nucleus Protein K48-linked Ubiquitination Catabolic Process Protein Modification Process Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Nucleotide Binding Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Regulation Of Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Nucleoplasm Mitochondrial Outer Membrane Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Proteolysis Cytoplasm Ubiquitin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process ATP Binding Regulation Of Post-translational Protein Modification Regulation Of Mitophagy Transferase Activity Protein Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process
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