GCK and PCNA

Number of citations of the paper that reports this interaction (PMID 20849852)
6

Data Source:
BioGRID (pull down)

		GCK	PCNA
Gene Name		glucokinase (hexokinase 4)	proliferating cell nuclear antigen
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Actin Filament Secretory Granule Basal Cortex	Nucleus Nucleoplasm DNA Replication Factor C Complex Cytoplasm Centrosome Nuclear Replication Fork PCNA Complex Extracellular Vesicular Exosome PCNA-p21 Complex
	Molecular Function	Magnesium Ion Binding Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Protein Phosphatase Binding ADP Binding	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Identical Protein Binding DNA Polymerase Binding
	Biological Process	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycogen Biosynthetic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Regulation Of Glycolytic Process NADP Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Hexose Transport Pathogenesis Regulation Of Glucose Transport Glucose Transport Second-messenger-mediated Signaling Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Negative Regulation Of Epinephrine Secretion Cellular Response To Insulin Stimulus Cellular Response To Glucose Starvation Positive Regulation Of Phosphorylation Glucose Homeostasis Regulation Of Potassium Ion Transport Small Molecule Metabolic Process Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Transmembrane Transport Lipid Homeostasis Calcium Ion Import	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Regulation Of DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Heart Development Cell Proliferation Translesion Synthesis Epithelial Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Lipid Response To Cadmium Ion
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein SLC-mediated transmembrane transport Hexose transport Regulation of beta-cell development Myoclonic epilepsy of Lafora Glycogen storage diseases Regulation of gene expression in beta cells Glucose transport Metabolism of carbohydrates	Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance G1/S Transition Removal of DNA patch containing abasic residue G1/S-Specific Transcription Resolution of Abasic Sites (AP sites) Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Base Excision Repair E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand G0 and Early G1 Telomere C-strand (Lagging Strand) Synthesis S Phase Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs		Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907) Glycated hemoglobin levels ( 20858683 19096518) Glycemic traits ( 23575436) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109)
Protein-Protein Interactions		4 interactors: GCKR INS PCNA PFKFB2	116 interactors: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 EXO1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HLTF HUS1 ING1 KCTD13 LDHA LIG1 MCL1 MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A PARP1 PARP10 PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLL POLM PPP1CA PRKDC PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RNF8 RPA1 SEC23IP SETD8 SHPRH SIVA1 SMARCAD1 SPRTN SUB1 TCOF1 TDG TIRAP TMEM218 TPI1 UBB UBE2A UBE2B UBE2D3 UHRF2 UNG USP1 USP2 USP4 WDR48 WRN XRCC1 XRCC5 XRCC6 YBX1 ZBTB1
Entrez ID		2645	5111
HPRD ID		00680	01456
Ensembl ID		ENSG00000106633	ENSG00000132646
Uniprot IDs		P35557 Q53Y25	P12004
PDB IDs		1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH	1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3P87 3TBL 3VKX
Enriched GO Terms of Interacting Partners?		Regulation Of Glucose Metabolic Process Positive Regulation Of Glucokinase Activity Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Glucose Transport Hexose Transport Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Regulation Of Glucose Transport Regulation Of Catalytic Activity Positive Regulation Of Hormone Secretion Response To Organic Substance Lipid Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Carbohydrate Transport Positive Regulation Of Deoxyribonuclease Activity Regulation Of DNA Replication Positive Regulation Of Phosphorylation Glucose Metabolic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Glycogen Catabolic Process Leading Strand Elongation Carbohydrate Metabolic Process Response To Carbohydrate Positive Regulation Of Protein Secretion Regulation Of Insulin Secretion Hexose Metabolic Process Positive Regulation Of Metabolic Process Glucose Homeostasis Pathogenesis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Peptide Hormone Secretion Monosaccharide Metabolic Process Regulation Of Phosphorylation Regulation Of Hormone Secretion Homeostatic Process Positive Regulation Of Brown Fat Cell Differentiation Glucose Catabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Glucokinase Activity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Feeding Behavior Positive Regulation Of Secretion Positive Regulation Of Protein Transport Positive Regulation Of Respiratory Burst	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Cell Cycle Process Chromosome Organization Base-excision Repair Cellular Metabolic Process Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic Cell Cycle Mitotic Recombination Mismatch Repair Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Strand Elongation Cellular Response To Stimulus Response To Radiation Response To Stimulus Organelle Organization DNA-dependent DNA Replication Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To UV Double-strand Break Repair Nucleotide-excision Repair Response To Abiotic Stimulus Catabolic Process Somatic Diversification Of Immunoglobulins Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Cellular Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Cycle Response To Light Stimulus Cellular Macromolecule Catabolic Process
Tagcloud ?		15del26 a1c acanthosis boy department dysmorphic exam fasting glucose height hemoglobin hyperglycemia increment l maturity mmol mody2 mother mu mutational nigricans ogtt proband referred segregated shifted stable stature unremarkable	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		15del26 a1c acanthosis boy department dysmorphic exam fasting glucose height hemoglobin hyperglycemia increment l maturity mmol mody2 mother mu mutational nigricans ogtt proband referred segregated shifted stable stature unremarkable	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?