GCK and PFKFB2

Number of citations of the paper that reports this interaction (PMID 11522786)
16

Data Source:
HPRD (two hybrid)

		GCK	PFKFB2
Gene Name		glucokinase (hexokinase 4)	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Actin Filament Secretory Granule Basal Cortex	Cytosol
	Molecular Function	Magnesium Ion Binding Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Protein Phosphatase Binding ADP Binding	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycogen Biosynthetic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Regulation Of Glycolytic Process NADP Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Hexose Transport Pathogenesis Regulation Of Glucose Transport Glucose Transport Second-messenger-mediated Signaling Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Negative Regulation Of Epinephrine Secretion Cellular Response To Insulin Stimulus Cellular Response To Glucose Starvation Positive Regulation Of Phosphorylation Glucose Homeostasis Regulation Of Potassium Ion Transport Small Molecule Metabolic Process Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Transmembrane Transport Lipid Homeostasis Calcium Ion Import	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Lactate Metabolic Process Glycolytic Process Pathogenesis Response To Glucose Dephosphorylation Positive Regulation Of Insulin Secretion Positive Regulation Of Glucokinase Activity Small Molecule Metabolic Process Carbohydrate Phosphorylation
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein SLC-mediated transmembrane transport Hexose transport Regulation of beta-cell development Myoclonic epilepsy of Lafora Glycogen storage diseases Regulation of gene expression in beta cells Glucose transport Metabolism of carbohydrates	Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs		Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907) Glycated hemoglobin levels ( 20858683 19096518) Glycemic traits ( 23575436) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109)
Protein-Protein Interactions		4 interactors: GCKR INS PCNA PFKFB2	9 interactors: AKT1 GCK PRKAA1 PRKAA2 PRKACA PRKCA YWHAG YWHAQ YWHAZ
Entrez ID		2645	5208
HPRD ID		00680	01383
Ensembl ID		ENSG00000106633	ENSG00000123836
Uniprot IDs		P35557 Q53Y25	B4DY91 O60825
PDB IDs		1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH
Enriched GO Terms of Interacting Partners?		Regulation Of Glucose Metabolic Process Positive Regulation Of Glucokinase Activity Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Glucose Transport Hexose Transport Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Regulation Of Glucose Transport Regulation Of Catalytic Activity Positive Regulation Of Hormone Secretion Response To Organic Substance Lipid Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Carbohydrate Transport Positive Regulation Of Deoxyribonuclease Activity Regulation Of DNA Replication Positive Regulation Of Phosphorylation Glucose Metabolic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Glycogen Catabolic Process Leading Strand Elongation Carbohydrate Metabolic Process Response To Carbohydrate Positive Regulation Of Protein Secretion Regulation Of Insulin Secretion Hexose Metabolic Process Positive Regulation Of Metabolic Process Glucose Homeostasis Pathogenesis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Peptide Hormone Secretion Monosaccharide Metabolic Process Regulation Of Phosphorylation Regulation Of Hormone Secretion Homeostatic Process Positive Regulation Of Brown Fat Cell Differentiation Glucose Catabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Glucokinase Activity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Feeding Behavior Positive Regulation Of Secretion Positive Regulation Of Protein Transport Positive Regulation Of Respiratory Burst	Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Glucose Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Peptide Hormone Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Peptide Regulation Of Establishment Of Protein Localization Positive Regulation Of Signal Transduction Energy Reserve Metabolic Process Apoptotic Signaling Pathway Histone Phosphorylation Regulation Of Protein Localization Regulation Of Apoptotic Process Membrane Organization Regulation Of Cell Death Response To Peptide Hormone Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Glucose Homeostasis Response To Peptide Cellular Response To Insulin Stimulus Regulation Of Glucose Import Negative Regulation Of Glucose Import Positive Regulation Of Glycolytic Process Regulation Of Cellular Localization Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Intracellular Transport Regulation Of Signaling Cellular Response To Hormone Stimulus Regulation Of Mitochondrion Organization Negative Regulation Of Glucose Transport Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Transport Regulation Of Protein Kinase Activity Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Regulation Of Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Response To Organonitrogen Compound Negative Regulation Of Transport Glucose Metabolic Process Chemical Homeostasis Generation Of Precursor Metabolites And Energy Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process
Tagcloud ?		15del26 a1c acanthosis boy department dysmorphic exam fasting glucose height hemoglobin hyperglycemia increment l maturity mmol mody2 mother mu mutational nigricans ogtt proband referred segregated shifted stable stature unremarkable
Tagcloud (Difference) ?		15del26 a1c acanthosis boy department dysmorphic exam fasting glucose height hemoglobin hyperglycemia increment l maturity mmol mody2 mother mu mutational nigricans ogtt proband referred segregated shifted stable stature unremarkable
Tagcloud (Intersection) ?